23441-87-4

Basic information

• Product Name: Wy 19190
• CAS NO: 23441-87-4
• Molecular Weight: 291.136
• Mol File: 23441-87-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Wy 19190(CAS DataBase Reference)
• NIST Chemistry Reference: Wy 19190(23441-87-4)
• EPA Substance Registry System: Wy 19190(23441-87-4)

Safety Data

• Hazardous Substances Data: 23441-87-4(Hazardous Substances Data)

Upstream product

• 846-49-1 lorazepam 
• 2958-36-3 (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone 
• 1189-71-5 isocyanate de chlorosulfonyle 

Downstream Products

• 86892-33-3 2,6-dichloro 4-(2-chloro phenyl)-quinazoline 
• 95854-75-4 [6-Chloro-4-(2-chloro-phenyl)-quinazolin-2-yl]-hydrazine 
• 100672-12-6 6-Chloro-4-(2-chloro-phenyl)-2-(3,5-dimethyl-pyrazol-1-yl)-quinazoline 
• 100681-23-0 6-Chloro-4-(2-chloro-phenyl)-2-(3,3,5-trimethyl-2,3-dihydro-pyrazol-1-yl)-quinazoline 
• 100672-15-9 2-[6-Chloro-4-(2-chloro-phenyl)-quinazolin-2-yl]-5-methyl-2,4-dihydro-pyrazol-3-one 
• 100672-20-6 5-Amino-2-[6-chloro-4-(2-chloro-phenyl)-quinazolin-2-yl]-1,2-dihydro-pyrazol-3-one 
• 100672-23-9 1-[6-Chloro-4-(2-chloro-phenyl)-quinazolin-2-yl]-4-phenyl-1H-pyrazol-3-ylamine 

Relevant articles and documents

Study of the lorazepam: Cyclodextrin inclusion complexes using electrospray ionization mass spectrometry

As an example of drug-cyclodextrin interactions in aqueous media, the cyclodextrin complexation of lorazepam was studied by electrospray ionization mass spectroscopy (ES-MS). It was concluded that highly concentrated aqueous hydroxypropylcyclodextrins are more suited for the drug complexation and that the inclusion complex includes one molecule of the drug with two and three cyclodextrin molecules as well as two molecules of the drug with three molecules of hydroxypropylcyclodextrins. It was postulated that in the hydroxycyclodextrin cavity the drug molecule decomposes via the elimination of one molecule of formaldehyde.

Production of quinazolinone compounds

2(1H)-Quinazolinone derivatives, which are useful as anti-inflammatory agents, are prepared by heating or hydrolyzing an acylurea derivative. The acylurea derivative can be prepared by either reacting an indole derivative with an oxidizing agent or reacti