23442-22-0

Basic information

• Product Name: 3-butoxy-4-aminobenzoic acid
• Synonyms: 3-butoxy-4-aminobenzoic acid;4-Amino-3-butoxybenzoic acid
• CAS NO: 23442-22-0
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.2417
• Mol File: 23442-22-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 123-125 °C
• Boiling Point: 383.501 °C at 760 mmHg
• Flash Point: 185.735 °C
• Appearance: /
• Density: 1.177 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.72±0.10(Predicted)
• CAS DataBase Reference: 3-butoxy-4-aminobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-butoxy-4-aminobenzoic acid(23442-22-0)
• EPA Substance Registry System: 3-butoxy-4-aminobenzoic acid(23442-22-0)

Safety Data

• Hazardous Substances Data: 23442-22-0(Hazardous Substances Data)

Usage

General Description

3-Butoxy-4-aminobenzoic acid is an organic compound that consists of a benzene ring with a carboxylic acid group (COOH) and an amino group (NH2) attached at the 4 and 3 positions, respectively. Additionally, a butoxy group is attached to the benzene ring at the 3 position. This chemical is commonly used in sunscreen formulations as a UV filter due to its ability to absorb UVB radiation. It works by absorbing and dissipating the energy from the sun's UV radiation, thus preventing damage to the skin. Furthermore, it is considered to be a safe and effective ingredient in sunscreen products, providing protection against sunburn and reducing the risk of skin cancer caused by UV exposure.

Synthetic route

benoxinate (99-43-4) → 3-butoxy-4-aminobenzoic acid (23442-22-0)

Conditions	Yield
With hydrogenchloride In water at 110℃; for 2h;

3-butoxy-4-aminobenzoic acid (23442-22-0) → 4-Amino-3-butoxy-benzoyl chloride (23442-23-1)

Conditions	Yield
With thionyl chloride at 50℃; for 0.5h;

3-butoxy-4-aminobenzoic acid (23442-22-0) + acetic anhydride (108-24-7) → 3-butoxy-4-acetylaminobenzoic acid

Conditions	Yield
for 1h; Ambient temperature;

3-butoxy-4-aminobenzoic acid (23442-22-0) → N-(3-butoxy-4-aminobenzoyl)glycine

Conditions	Yield
Multi-step reaction with 2 steps 1: thionyl chloride / 0.5 h / 50 °C 2: 10percent NaOH / H2O / 1 h / 0 °C View Scheme

Upstream product

• 99-43-4 benoxinate 

Downstream Products

• 23442-23-1 4-Amino-3-butoxy-benzoyl chloride 

Relevant articles and documents

Metabolism of benoxinate in humans

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