2345-68-8Relevant articles and documents
MACROCYCLIC CHLORINE SUBSTITUTED INDOLE DERIVATIVES
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Page/Page column 358, (2019/06/13)
The present invention relates to macrocyclic indole derivatives of general formula (I) : (I), in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active 10 ingredients.
Phosphine ligands in the Palladium-catalysed methoxycarbonylation of ethene: Insights into the catalytic cycle through an HP NMR spectroscopic Study
De La Fuente, Veronica,Waugh, Mark,Eastham, Graham R.,Iggo, Jonathan A.,Castillon, Sergio,Claver, Carmen
scheme or table, p. 6919 - 6932 (2010/08/07)
Novel cis-1,2-bis(di-tertbutyl-phosphinomethyl) carbocyclic ligands 6-9 have been prepared and the corresponding palladium complexes [Pd(O 3SCH3)(L-L)][O3SCH3] (L-L = diphosphine) 32-35 synthesised and characterised by NMR spectroscopy and Xray diffraction. These diphosphine ligands give very active catalysts for the palladium-catalysed methoxycarbonylation of ethene. The activity varies with the size of the carbocyclic backbone, ligands 7 and 9, containing four- and six-membered ring backbones giving more active systems. The acid used as co-catalyst has a strong influence on the activity, with excess trifluoroacetic acid affording the highest conversion, whereas excess methyl sulfonic acid inhibits the catalytic system. An in oper-ando NMR spectroscopic mechanistic study has established the catalytic cycle and resting state of the catalyst under operating reaction conditions. Although the catalysis follows the hydride pathway, the resting state is shown to be the hydride precursor complex [Pd(O3SCH3)(L-L)][O3SCH3], which demonstrates that an isolable/detectable hydride complex is not a prerequisite for this mechanism.
Enantioselective hydrolysis of cis-1,2-diacetoxycycloalkanedimethanols: enzymatic preparation of chiral building blocks from prochiral meso-substrates.
Laumen, Kurt,Schneider, Manfred
, p. 2073 - 2076 (2007/10/02)
The enzymatic hydrolysis of the prochiral title compounds 1a-f in presence of porcine liver esterase (PLE) and lipase from porcine pancreas (PPL) was studied, resulting in the preparation of the chiral monoacetates 2b-f with high (72-99percente.e.) enantiomeric purities.