2347-38-8

Basic information

• Product Name: 4-(dipropylamino)-3,5-dinitrobenzoic acid
• Synonyms: Benzoic acid, 4-(dipropylamino)-3,5-dinitro-
• CAS NO: 2347-38-8
• Molecular Formula: C₁₃H₁₇N₃O₆
• Molecular Weight: 311.2906
• Mol File: 2347-38-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 461.1°C at 760 mmHg
• Flash Point: 232.7°C
• Density: 1.355g/cm³
• Vapor Pressure: 2.67E-09mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: 4-(dipropylamino)-3,5-dinitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(dipropylamino)-3,5-dinitrobenzoic acid(2347-38-8)
• EPA Substance Registry System: 4-(dipropylamino)-3,5-dinitrobenzoic acid(2347-38-8)

Safety Data

• Hazardous Substances Data: 2347-38-8(Hazardous Substances Data)

Upstream product

• 142-84-7 di-n-propylamine 
• 118-97-8 4-chloro-3,5-dinitrobenzoic acid 

Downstream Products

• 36317-67-6 4-dipropylamino-3,5-dinitro-benzoyl chloride 
• 2078-11-7 4-dipropylamino-3,5-dinitro-benzoic acid methyl ester 

Relevant articles and documents

Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides

N1-Phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (1) and N1-phenyl-3,5-dinitro-N4,N4-di-n-butylsulfanilamide (2) show potent in vitro antimitotic activity against kinetoplastid parasites but display poor in vivo activity. Seventeen new dinitroaniline sulfonamide and eleven new benzamide analogs of these leads are reported here. Nine of the sulfonamides display in vitro IC50 values under 500 nM against African trypanosomes, and the most active antikinetoplastid compounds also inhibit the in vitro assembly of purified leishmanial tubulin with potencies similar to that of 2. While several of the potent compounds are rapidly degraded by rat liver S9 fractions in vitro, N1-(3-hydroxy)phenyl-3,5-dinitro-N4,N4-di-n-butylsulfanilamide (21) displays an IC50 value of 260 nM against African trypanosomes in vitro and is more stable than 2 in the in vitro metabolism assay.