23511-05-9

Basic information

• Product Name: 1,4-Dioxaspiro[4.5]decan-8-ol 4-methylbenzenesulfonate
• Synonyms: 1,4-Dioxaspiro[4.5]decan-8-ol 4-methylbenzenesulfonate;1,4-Dioxaspiro[4.5]decan-8-yl 4-Methylbenzenesulfonate
• CAS NO: 23511-05-9
• Molecular Formula: C₁₅H₂₀O₅S
• Molecular Weight: 312.38
• Mol File: 23511-05-9.mol
• Article Data: 32

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,4-Dioxaspiro[4.5]decan-8-ol 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dioxaspiro[4.5]decan-8-ol 4-methylbenzenesulfonate(23511-05-9)
• EPA Substance Registry System: 1,4-Dioxaspiro[4.5]decan-8-ol 4-methylbenzenesulfonate(23511-05-9)

Safety Data

• Hazardous Substances Data: 23511-05-9(Hazardous Substances Data)

Usage

Chemical Structure

A nucleotide analog derivative of the antiviral drug stavudine.

Function

Acts as a prodrug, which is converted into its active form in the body.

Mechanism of Action

Inhibits the reverse transcriptase enzyme, crucial for viral replication.

Purpose

Used in the treatment of HIV infection.

Additional Studies

Investigated for potential use in combination therapy for HIV and other viral infections.

Upstream product

• 22428-87-1 4,4-ethylenedioxycyclohexan-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 54498-70-3 <4-D1>Cyclohexanon 
• 23510-98-7 4-(methylthio)cyclohexan-1-one 
• 478364-11-3 4-[(1-phenylsulfonyl)ethyl]cyclohexan-1-one ethylene ketal 
• 478364-15-7 4-[(1-phenylsulfonyl)ethyl]cyclohexan-1-one 
• 55103-51-0 8-(methylthio)-1,4-dioxaspiro[4.5]decane 
• 262441-40-7 5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4,5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 164720-94-9 4-[O-benzyl-N-(1,4-dioxaspiro[4.5]dec-8-yl)hydroxylamino]-3-methoxy-2-methylpyridine 
• 1032826-73-5 [5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl][3-(1,4-dioxaspiro[4.5]dec-8-yloxy)phenyl]methanone 
• 1227611-94-0 4-(4-iodo-1H-pyrazol-1-yl)cyclohexanone 
• 1350324-96-7 trans-4-(4-{3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3-methoxy-1H-pyrazol-1-yl)cyclohexanol 
• 1350325-01-7 trans-4-[4-(3-{(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]ethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-methoxy-1H-pyrazol-1-yl]cyclohexanol 
• 1350322-63-2 trans-4-(4-{3-[(1S)-1-(2-Chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3,5-dimethyl-1H-pyrazol-1-yl)cyclohexanol 
• 1350322-65-4 1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-3,5-dimethyl-1H-pyrazole 
• 1350322-66-5 trans-4-(4-iodo-3,5-dimethyl-1H-pyrazol-1-yl)cyclohexanol 

Relevant articles and documents

Electron Impact Mass Spectrometry of 3-Cyclohexen-1-ol and Related Compounds

The electron impact mass spectrum of 3-cyclohexen-1-ol has been studied, especially with regard to retro Diels-Alder reaction.Six deuterium labelled analogues and two dimethyl substituted homologues were synthesised.Contrary to what we have observed with 2-cyclohexen-1-ol, the double bond migration which precedes the retro Diels-Alder reaction plays a minor role.

COMPOUND SERVING AS IRAK INHIBITOR

The present disclosure relates a compound as an IRAK inhibitor. Specifically, the present disclosure provides a compound of formula I, or a cis-trans isomer, an optical isomer, a racemate, a pharmaceutically acceptable salt, a prodrug, a deuterated derivative thereof, a hydrate or a solvate thereof. The compounds disclosed herein have potent inhibitory effects on IRAK and thus have therapeutic effect on IRAK-related diseases.

AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF

Disclosed herein is an aminopyrazine compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.