23515-44-8

Basic information

• Product Name: (2R,3S)-5-(2-DIMETHYLAMINO-ETHYL)-3-HYDROXY-2-(4-METHOXY-PHENYL)-2,3-DIHYDRO-5H-BENZO[B][1,4]THIAZEPIN-4-ONE
• Synonyms: (2R,3S)-5-(2-DIMETHYLAMINO-ETHYL)-3-HYDROXY-2-(4-METHOXY-PHENYL)-2,3-DIHYDRO-5H-BENZO[B][1,4]THIAZEPIN-4-ONE
• CAS NO: 23515-44-8
• Molecular Formula: C₂₀H₂₄N₂O₃S
• Molecular Weight: 372.48116
• Mol File: 23515-44-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R,3S)-5-(2-DIMETHYLAMINO-ETHYL)-3-HYDROXY-2-(4-METHOXY-PHENYL)-2,3-DIHYDRO-5H-BENZO[B][1,4]THIAZEPIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-5-(2-DIMETHYLAMINO-ETHYL)-3-HYDROXY-2-(4-METHOXY-PHENYL)-2,3-DIHYDRO-5H-BENZO[B][1,4]THIAZEPIN-4-ONE(23515-44-8)
• EPA Substance Registry System: (2R,3S)-5-(2-DIMETHYLAMINO-ETHYL)-3-HYDROXY-2-(4-METHOXY-PHENYL)-2,3-DIHYDRO-5H-BENZO[B][1,4]THIAZEPIN-4-ONE(23515-44-8)

Safety Data

• Hazardous Substances Data: 23515-44-8(Hazardous Substances Data)

Usage

Description

(2R,3S)-5-(2-DIMETHYLAMINO-ETHYL)-3-HYDROXY-2-(4-METHOXY-PHENYL)-2,3-DIHYDRO-5H-BENZO[B][1,4]THIAZEPIN-4-ONE is a complex organic molecule characterized by a 5H-benzo[b][1,4]thiazepin-4-one core structure. It features a 2,3-dihydro-3-hydroxy-2-(4-methoxy-phenyl) group and a 2-dimethylamino-ethyl side chain. The specific 2R,3S stereochemistry of this molecule is crucial for its interactions with biological target molecules and its potential as a medicinal agent.

Uses

Used in Pharmaceutical Research:
(2R,3S)-5-(2-DIMETHYLAMINO-ETHYL)-3-HYDROXY-2-(4-METHOXY-PHENYL)-2,3-DIHYDRO-5H-BENZO[B][1,4]THIAZEPIN-4-ONE is utilized as a research compound for exploring its potential biological activity and therapeutic properties. Its unique structure and stereochemistry make it a valuable candidate for the development of new pharmaceuticals.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (2R,3S)-5-(2-DIMETHYLAMINO-ETHYL)-3-HYDROXY-2-(4-METHOXY-PHENYL)-2,3-DIHYDRO-5H-BENZO[B][1,4]THIAZEPIN-4-ONE serves as a key molecule for designing and optimizing drugs targeting specific biological pathways. Its stereochemistry plays a significant role in determining its efficacy and selectivity as a therapeutic agent.
Used in Drug Development:
(2R,3S)-5-(2-DIMETHYLAMINO-ETHYL)-3-HYDROXY-2-(4-METHOXY-PHENYL)-2,3-DIHYDRO-5H-BENZO[B][1,4]THIAZEPIN-4-ONE is employed in drug development as a lead compound. Its unique structural features and stereochemistry are leveraged to create new drugs with improved potency, selectivity, and reduced side effects.
Used in Chemical Synthesis:
In the realm of chemical synthesis, (2R,3S)-5-(2-DIMETHYLAMINO-ETHYL)-3-HYDROXY-2-(4-METHOXY-PHENYL)-2,3-DIHYDRO-5H-BENZO[B][1,4]THIAZEPIN-4-ONE is used as a starting material or intermediate for the synthesis of other complex organic molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 33286-22-5 diltiazem hydrochloride 
• 27068-88-8 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 
• 107-99-3 2-(dimethylamino)ethyl chloride 
• 27068-88-8 3c-hydroxy-2r-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 96125-49-4 methyl trans-3-(4-methoxyphenyl)glycidate 
• 123-11-5 4-methoxy-benzaldehyde 
• 30193-56-7 (+/-)-(R*,R*)-β-[(2-aminophenyl)thio]-α-hydroxy-4-methoxybenzenepropanoic acid, methyl ester 
• 42245-42-1 methyl (2-RS,3-SR)-2,3-epoxy-3-(4-methoxyphenyl)propanoate 
• 137-07-5 2-amino-benzenethiol 
• 154076-93-4 ethyl (Z)-2-(2-methoxyethoxy)methoxy-3-(4-methoxyphenyl)-2-propenoate 
• 80344-17-8 3-[2-(2-dimethylamino-ethylamino)-phenylsulfanyl]-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid 

Downstream Products

• 40602-19-5 3c-butyryloxy-5-(2-dimethylamino-ethyl)-2r-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 48218-47-9 5-(2-dimethylamino-ethyl)-3c-ethoxy-2r-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 31953-21-6 3-methyl-butyric acid 5-(2-dimethylamino-ethyl)-2c-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3r-yl ester 
• 40602-20-8 5-(2-dimethylamino-ethyl)-2r-(4-methoxy-phenyl)-3c-pentanoyloxy-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 40602-22-0 5-(2-dimethylamino-ethyl)-3c-hexanoyloxy-2r-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 40602-18-4 5-(2-dimethylamino-ethyl)-2r-(4-methoxy-phenyl)-3c-propionyloxy-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 28739-41-5 5-(2-dimethylamino-ethyl)-3c-ethoxycarbonyloxy-2r-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 34933-06-7 (+/-)-Diltiazem 
• 34933-06-7 3t-acetoxy-5-(2-dimethylamino-ethyl)-2r-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 33286-23-6 5-(2-dimethylamino-ethyl)-3c-hydroxy-2r-(4-hydroxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 68767-07-7 5-(2-dimethylamino-ethyl)-3c-hydroxy-2r-(4-methoxy-phenyl)-1ξ-oxo-1,2,3,5-tetrahydro-1λ⁴-benzo[b][1,4]thiazepin-4-one 
• 68767-08-8 5-[2-(dimethyl-oxy-amino)-ethyl]-3c-hydroxy-2r-(4-methoxy-phenyl)-1ξ-oxo-1,2,3,5-tetrahydro-1λ⁴-benzo[b][1,4]thiazepin-4-one 
• 68767-09-9 5-[2-(dimethyl-oxy-amino)-ethyl]-3c-hydroxy-2r-(4-methoxy-phenyl)-1,1-dioxo-1,2,3,5-tetrahydro-1λ⁶-benzo[b][1,4]thiazepin-4-one 
• 68767-06-6 5-[2-(dimethyl-oxy-amino)-ethyl]-3c-hydroxy-2r-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 

Relevant articles and documents

COMPOUNDS AS MODULATORS OF GHRELIN RECEPTOR AND USES THEREOF

Disclosed herein are compounds of Formula (I) as defined herein, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, that selectively activate the ghrelin receptor, and pharmaceutical compositions comprising the same. Disclosed herein are also methods of treatment of diseases and disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I).

cis-(±)-5-[2- (Dimethylamino)ethyl]-3-hydroxy-2-(4- methoxyphenyl )-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one

The title compound, C20H24N2O3S, is a drug intermediate of diltiazem. The molecule is stabilized by covalent bonding and weak hydrogen bonding, and the crystal packing is stabilized by hydrogen bonding. The seven-membered ring is distorted showing a twist-boat conformation. The methoxyphenyl and hydroxy groups are cis oriented with respect to one another, with the phenyl ring in an axial position. Intermolecular hydrogen bonding produces dimers in the crystal.

Naphthalene derivatives and method for preparation thereof

A naphthalene derivative of the formula: STR1 wherein R1 is hydrogen and R2 is lower alkyl or phenyl-lower alkyl; or R1 and R2 are combined together to form lower alkylene; X is halogen; and the absolute configu