23551-25-9 Usage
Description
Bis Des-iodo amiodarone HCl (Amiodarone impurity) is an intermediate compound derived from the synthesis of Amiodarone, a well-known antiarrhythmic medication. It is characterized by its pale yellow oil appearance and plays a significant role in the production process of Amiodarone.
Uses
Used in Pharmaceutical Industry:
Bis Des-iodo amiodarone HCl (Amiodarone impurity) is used as an intermediate in the synthesis of Amiodarone for the treatment of various cardiac arrhythmias. Its role in the production process is crucial, as it contributes to the development of the final drug product, which is effective in managing abnormal heart rhythms and preventing life-threatening conditions.
Additionally, due to its chemical properties, Bis Des-iodo amiodarone HCl (Amiodarone impurity) may also be utilized in research and development for the creation of new pharmaceutical compounds with potential applications in cardiology and other related fields.
Check Digit Verification of cas no
The CAS Registry Mumber 23551-25-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,5,5 and 1 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 23551-25:
(7*2)+(6*3)+(5*5)+(4*5)+(3*1)+(2*2)+(1*5)=89
89 % 10 = 9
So 23551-25-9 is a valid CAS Registry Number.
23551-25-9Relevant articles and documents
Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites
Snead, Aaron N.,Miyakawa, Motonori,Tan, Edwin S.,Scanlan, Thomas S.
supporting information; experimental part, p. 5920 - 5922 (2009/05/31)
Amiodarone (Cordarone, Wyeth-Ayerst Pharmaceuticals) is a clinically available drug used to treat a wide variety of cardiac arrhythmias. We report here the synthesis and characterization of a panel of potential amiodarone metabolites that have significant structural similarity to thyroid hormone and its metabolites the iodothyronamines. Several of these amiodarone derivatives act as specific agonists of the G protein-coupled receptor (GPCR) trace amine-associated receptor 1 (TAAR1). This result demonstrates a novel molecular target for amiodarone derivatives with potential clinical significance.
