23551-92-0Relevant articles and documents
Simple and convenient access to α,α,α-trisubstituted amides by double addition of Grignard reagents to acyl cyanohydrins
Boukattaya, Fatma,Stanovych, Andrii,Setzer, Paul,Abid, Souhir,Ammar, Houcine,Pearson-Long, Morwenna S. M.,Bertus, Philippe
supporting information; experimental part, p. 8655 - 8657 (2012/10/08)
The double addition of Grignard (alkyl, aryl, alkenyl, alkynyl) reagents to acyl cyanohydrins was performed under unusually smooth conditions with a concomitant O-N acyl transfer, providing a very simple and general access to α,α,α-trisubstituted amides.
