23582-03-8 Usage
Description
TRIS[2-(DIPHENYLPHOSPHINO)ETHYL]PHOSPHINE is a white to light yellow crystalline powder that has been enhanced for catalytic efficiency. It is a phosphine ligand with a unique structure, featuring a tris(2-(diphenylphosphino)ethyl) backbone and a phosphine group. This structure contributes to its high catalytic activity and selectivity in various chemical reactions.
Uses
Used in Pharmaceutical Industry:
TRIS[2-(DIPHENYLPHOSPHINO)ETHYL]PHOSPHINE is used as a ligand for the fast and selective iron-catalyzed transfer hydrogenations of aldehydes. This application is particularly relevant in the synthesis of pharmaceutical compounds, where the reduction of aldehydes to alcohols is a common step. The use of this ligand allows for a greener and more efficient reduction process, reducing waste and improving the overall sustainability of the synthesis.
Used in Chemical Synthesis:
In the field of chemical synthesis, TRIS[2-(DIPHENYLPHOSPHINO)ETHYL]PHOSPHINE is used as a ligand to improve the efficiency and selectivity of iron-catalyzed transfer hydrogenations. This is particularly useful in the synthesis of complex organic molecules, where the control of reaction conditions and the minimization of side products are crucial. The use of this ligand can lead to faster reaction times and higher yields, making it a valuable tool for chemists working in this area.
Used in Green Chemistry:
TRIS[2-(DIPHENYLPHOSPHINO)ETHYL]PHOSPHINE is used as a ligand in iron-catalyzed, greener reduction of aldehydes to alcohols under transfer hydrogenation conditions. This application is important in the field of green chemistry, where the development of more environmentally friendly and sustainable chemical processes is a priority. The use of this ligand can help to reduce the amount of waste generated during chemical reactions and improve the overall efficiency of the process, contributing to a more sustainable approach to chemical synthesis.
Reaction
Ligand used in the ruthenium-catalyzed hydrogenation of carbon dioxide facilitated by catalytic quantities of bicarbonate.
Ligand used in the selective iron-catalyzed transfer hydrogenation of terminal alkynes.
Ligand used in the selective iron-catalyzed transfer hydrogenation of nitoarenes, without base.
Check Digit Verification of cas no
The CAS Registry Mumber 23582-03-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,5,8 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 23582-03:
(7*2)+(6*3)+(5*5)+(4*8)+(3*2)+(2*0)+(1*3)=98
98 % 10 = 8
So 23582-03-8 is a valid CAS Registry Number.
InChI:InChI=1/C42H42P4/c1-7-19-37(20-8-1)44(38-21-9-2-10-22-38)34-31-43(32-35-45(39-23-11-3-12-24-39)40-25-13-4-14-26-40)33-36-46(41-27-15-5-16-28-41)42-29-17-6-18-30-42/h1-30H,31-36H2
23582-03-8Relevant articles and documents
A Mild One-Pot Reduction of Phosphine(V) Oxides Affording Phosphines(III) and Their Metal Catalysts
Kapu?niak, ?ukasz,Plessow, Philipp N.,Trzybiński, Damian,Wo?niak, Krzysztof,Hofmann, Peter,Jolly, Phillip Iain
supporting information, p. 693 - 701 (2021/04/06)
The metal-free reduction of a range of phosphine(V) oxides employing oxalyl chloride as an activating agent and hexachlorodisilane as reducing reagent has been achieved under mild reaction conditions. The method was successfully applied to the reduction of industrial waste byproduct triphenylphosphine(V) oxide, closing the phosphorus cycle to cleanly regenerate triphenylphosphine(III). Mechanistic studies and quantum chemical calculations support the attack of the dissociated chloride anion of intermediated phosphonium salt at the silicon of the disilane as the rate-limiting step for deprotection. The exquisite purity of the resultant phosphine(III) ligands after the simple removal of volatiles under reduced pressure circumvents laborious purification prior to metalation and has permitted the facile formation of important transition metal catalysts.
Synthesis of aldehydes from alcohols
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, (2008/06/13)
A catalyst has been found for the low pressure hydroformylation of alcohols to produce aldehydes. This catalyst consists of a rhodium containing compound, an iodide containing compound, and a chelating Group V compound, which is used alone or in combination with a monodentate, Group V compound. It is the first rhodium-based catalyst that generates acetaldehyde via hydroformylation of the methanol. The reaction is typically carried out at 160°-180° C. and 1000-2000 psi. The acetaldehyde rate and selectivity are 1-5 Mhr-1 and 50-75%. Conventional cobalt catalysts require operating pressures of at least 3000-6000 psi in order to obtain reasonable productivities.
