23582-63-0Relevant articles and documents
Lysine sulfonamides as novel HIV-Protease inhibitors: Optimization of the Nε-acyl-phenyl spacer
Stranix, Brent R.,Sauve, Gilles,Bouzide, Abderrahim,Cote, Alexandre,Sevigny, Guy,Yelle, Jocelyn
, p. 4289 - 4292 (2007/10/03)
A series of Nα-isobutyl-Nα-arylsulfonamido-(Nε acyl) lysine and lysinol derivatives were prepared and evaluated as inhibitors of HIV protease and wild type virus. A simple original synthesis was devised to form Nα-(arylsulfonamide)-Nα-isobutyl lysine, whi
PROCESS FOR PREPARING MORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS
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, (2008/06/13)
Substituted heterocycles of the general structural formula: STR1 are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.