23593-74-0Relevant articles and documents
1,(3,)5-substituted imidazoles, useful in the treatment of hypertension and methods for their preparation
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Paragraph 0171, (2016/03/04)
The present invention provides novel 1,5 and 1,3,5-substituted imidazole compounds in hydrophilic or lipophilic form, which are useful as angiotensin II ATI receptor antagonists suitable for transdermal delivery. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing compounds and their use in methods of treating hypertension and cardiovascular diseases.
Access to aromatic ring-fused benzimidazoles using photochemical substitutions of the benzimidazol-2-yl radical
Oconnell, Joanne M.,Moriarty, Eoin,Aldabbagh, Fawaz
, p. 3371 - 3377 (2013/01/15)
Photochemical five-, six-, and seven-membered cyclizations from 2-iodo-1-(ω-arylalkyl)-1H-benzimidazoles are described. This method of producing aromatic ring-fused benzimidazoles is significantly more efficient than literature radical protocols using chemical initiators, although 2-iodo-1-(ω-pyridin-2-ylalkyl)-1H-benzimidazoles preferentially undergo a nucleophilic ipso-substitution onto the benzimidazole-2-position. Georg Thieme Verlag Stuttgart - New York.
Benzimidazoles as ligands in the ruthenium-catalyzed enantioselective bifunctional hydrogenation of ketones
Praetorius, Jeremy M.,Wang, Ruiyao,Crudden, Cathleen M.
experimental part, p. 554 - 561 (2010/04/25)
A series of Cl2Ru(diphosphane)L2 (II) complexes in which L = N1-alkylated benzimidazoles, bonding to the metal through nitrogen, have been synthesized and characterized. In the case of 1-methylbenzimidazole, the resulting complexes exist as statistical mixtures of all possible conformational isomers. When the size of the substituent on the benzimidazole was increased to complexes could be prepared that exist as a single diastereomer. All complexes possessing benzimidazole ligands bound to the ruthenium center are active for the mild and chemoselective hydrogenation of ketones in the presence of alkenes. Catalysts that exist as a single diastereomer, prepared with enantiomerically pure diphosphanes, catalyze the hydrogenation of prochiral ketones with moderate levels of enantioselectivity that are significantly improved relative to catalysts existing in several conformations.
