23597-82-2

Basic information

• Product Name: Hexyl nicotinoate
• Synonyms: 3-Pyridinecarboxylic acid, hexyl ester;3-pyridinecarboxylicacid,hexylester;Nicotherm;N-HEXYL NICOTINATE;n-Hexyl nicotinoate;NICOTINIC ACID N-HEXYL ESTER;NICOTINIC ACID HEXYL ESTER;HEXYL PYRIDINE-3-CARBOXYLATE
• CAS NO: 23597-82-2
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.27
• EINECS: 245-767-4
• Mol File: 23597-82-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 140°C
• Flash Point: 127.8 °C
• Appearance: /
• Density: 1,02 g/cm3
• Vapor Pressure: 0.000181mmHg at 25°C
• Refractive Index: 1.4880 to 1.4920
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.21±0.10(Predicted)
• Water Solubility: 0.17g/L(32 oC)
• CAS DataBase Reference: Hexyl nicotinoate(CAS DataBase Reference)
• NIST Chemistry Reference: Hexyl nicotinoate(23597-82-2)
• EPA Substance Registry System: Hexyl nicotinoate(23597-82-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 23597-82-2(Hazardous Substances Data)

Usage

Description

Hexyl nicotinate is an active substance belonging to the group of rubefacients, which are known for their ability to stimulate blood circulation. It is a nicotinic acid ester prodrug that rapidly penetrates and dilates blood vessels, temporarily enhancing blood flow. This increased circulation leads to a better supply of oxygen, nutrients, and moisture to the skin cells, as well as a faster elimination of waste through the metabolic process.

Uses

1. Used in the pharmaceutical industry:
Hexyl nicotinate is used as a topical treatment for muscle, joint, and ligament pain. It is commonly found in creams, baths, and emulsions, and can be used in both veterinary and human medicines.
2. Used in the cosmetic industry:
Hexyl nicotinate is used as a cosmetic ingredient in various applications, such as sun tanning lotions, creams, slimming gels, and creams. It is preferred over niacin due to its better penetrating power.
a. Hair loss creams and lotions:
Hexyl nicotinate is used as a vasodilator in hair loss creams and lotions, promoting better blood circulation to the scalp and potentially aiding in hair growth.
b. Ingredient in Transvasin heat rub cream (Thornton & Ross):
Hexyl nicotinate is an ingredient in Transvasin heat rub cream, which is used to provide relief from muscle and joint pain.
c. Slimming and tanning cosmetic formulations:
Hexyl nicotinate is used in almost all slimming and tanning cosmetic formulations due to its ability to enhance blood circulation and improve the appearance of the skin.

benefits

1. Preferred over Niacin due to its better penetrating power.2. Hexyl Nicotinate demonstrates better rubefacient properties which can produce pronounced thermo-slimming compositions.3. Hexyl Nicotinate enhances blood circulation in the skin and enhances the skin's metabolism.

InChI:InChI=1/C12H17NO2/c1-2-3-4-5-9-15-12(14)11-7-6-8-13-10-11/h6-8,10H,2-5,9H2,1H3

Upstream product

• 59-67-6 nicotinic acid 
• 111-27-3 hexan-1-ol 
• 490-11-9 3,4-pyridinecarboxylic acid 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 

Relevant articles and documents

Ionic liquids provide unique opportunities for oral drug delivery: Structure optimization and in vivo evidence of utility

Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.