23618-30-6

Basic information

• Product Name: 2-Propen-1-one, 1-(2-benzofuranyl)-3-phenyl-
• CAS NO: 23618-30-6
• Molecular Formula: C17H12O2
• Molecular Weight: 248.281
• Mol File: 23618-30-6.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(2-benzofuranyl)-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(2-benzofuranyl)-3-phenyl-(23618-30-6)
• EPA Substance Registry System: 2-Propen-1-one, 1-(2-benzofuranyl)-3-phenyl-(23618-30-6)

Safety Data

• Hazardous Substances Data: 23618-30-6(Hazardous Substances Data)

Upstream product

• 1646-26-0 1-(benzo[b]furan-2-yl)ethanone 
• 100-52-7 benzaldehyde 
• 90-02-8 salicylaldehyde 
• 64-17-5 ethanol 

Downstream Products

• 1160579-00-9 1-(benzofuran-2-yl)-4-nitro-3-phenylbutan-1-one 
• 1244781-97-2 C₁₈H₁₄N₂O₂ 
• 139956-15-3 3-(benzofuran-2-yl)-5-phenyl-2-pyrazoline 
• 1246467-90-2 (3-benzo[b]furan-2-yl-5-phenyl-4,5-dihydro-1H-1-pyrazolyl)(4-pyridyl)methanone 
• 1173187-37-5 6-benzofuran-2-yl-4-phenyl-2-sulfanylpyridine-3carbonitrile 
• 1163744-60-2 C₃₃H₂₃N₅O₂ 

Relevant articles and documents

Asymmetric Epoxidation of Enones Promoted by Dinuclear Magnesium Catalyst

Asymmetric synthesis with cheaper and non-toxic alkaline earth metal catalysts is becoming an important and sustainable alternative to conventional catalytic methodologies mostly relying on precious metals. In spite of some sustainable methods for enantioselective epoxidation of enones, the development of a well-defined and efficient catalyst based on magnesium complexes for these reactions is still a challenging task. In this perspective, we present the application of chiral dinuclear magnesium complexes for asymmetric epoxidation of a broad range of electron-deficient enones. We demonstrate that the in situ generated magnesium-ProPhenol complex affords enantioenriched oxiranes in high yields and with excellent enantioselectivities (up to 99% ee). Our extensive study verifies the literature data in this area and provides a step forward to better understand the factors controlling the oxygenation process. Elaborated catalyst offers mild reaction conditions and a truly wide substrate scope. (Figure presented.).

Containing of a benzofuran compound miazines and its preparation and use

The invention discloses a benzofuran-containing pyrimidine compound with a structure shown in formula I and its pharmaceutically acceptable salt. The invention also discloses a preparation method of the compound, and also discloses a medicinal composition

Synthesis, Characterization, and Anticancer Activity of New Benzofuran Substituted Chalcones

Benzofuran derivatives are of great interest in medicinal chemistry and have drawn considerable attention due to their diverse pharmacological profiles including anticancer activity. Similarly, chalcones, which are common substructures of numerous natural products belonging to the flavonoid class, feature strong anticancer properties. A novel series of chalcones, 3-aryl-1-(5-bromo-1-benzofuran-2-yl)-2-propanones propenones (3a-f), were designed, synthesized, and characterized. In vitro antitumor activities of the newly synthesized (3a-f) and previously synthesized (3g-j) chalcone compounds were determined by using human breast (MCF-7) and prostate (PC-3) cancer cell lines. Antitumor properties of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell viability assay for the tested chalcone compounds was performed and the log I C 50 values of the compounds were calculated after 24-hour treatment. Our results indicate that the tested chalcone compounds show antitumor activity against MCF-7 and PC-3 cell lines (p 0.05).