23633-63-8

Basic information

• Product Name: 1-Dehydro Epiandrosterone
• Synonyms: 1-Dehydro Epiandrosterone;1-Androsterone;(3R,5S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-3,4,5,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
• CAS NO: 23633-63-8
• Molecular Formula: C₁₉H₂₈O₂
• Molecular Weight: 288.42442
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 23633-63-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 169-171 °C
• Boiling Point: 416.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.105±0.06 g/cm3(Predicted)
• PKA: 14.32±0.60(Predicted)
• CAS DataBase Reference: 1-Dehydro Epiandrosterone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Dehydro Epiandrosterone(23633-63-8)
• EPA Substance Registry System: 1-Dehydro Epiandrosterone(23633-63-8)

Safety Data

• Hazardous Substances Data: 23633-63-8(Hazardous Substances Data)

Usage

Description

1-Dehydro Epiandrosterone, also known as 1-Dehydroepiandrosterone, is an androsterone metabolite derived from the metabolism of androsterone, a naturally occurring steroid hormone. It is a white solid with distinct chemical properties that make it useful in various applications.

Uses

Used in Steroid Abuse Screenings:
1-Dehydro Epiandrosterone is used as a biomarker for the detection of steroid abuse screenings. Its presence in urine or blood samples can indicate the use of anabolic steroids, which are often abused for performance enhancement in sports or bodybuilding.
Used in Pharmaceutical Research:
1-Dehydro Epiandrosterone is used as a research compound in the pharmaceutical industry for the development of new drugs targeting steroid-related conditions. Its unique chemical properties and metabolic pathways make it a valuable tool in understanding the effects of steroid hormones on the human body.
Used in Analytical Chemistry:
1-Dehydro Epiandrosterone is used as a reference material in analytical chemistry for the calibration of instruments and the development of new methods for the detection and quantification of steroid hormones and their metabolites.
Used in Sports Medicine:
1-Dehydro Epiandrosterone is used as a diagnostic tool in sports medicine to identify athletes who may be using performance-enhancing drugs. Its detection in drug testing can lead to the enforcement of anti-doping regulations and maintain fair competition in sports.

Upstream product

• 51505-46-5 (3β,5α,17β)-3-hydroxyandrost-1-en-17-yl acetate 
• 64-82-4 (5α,17β)-3-oxoandrost-1-en-17-yl acetate 
• 571-40-4 5α-androst-1-ene-3,17-dione 

Relevant articles and documents

Seized designer supplement named "1-Androsterone": Identification as 3β-hydroxy-5α-androst-1-en-17-one and its urinary elimination

New analogues of androgens that had never been available as approved drugs are marketed as "dietary supplement" recently. They are mainly advertised to promote muscle mass and are considered by the governmental authorities in various countries, as well as by the World Anti-doping Agency for sport, as being pharmacologically and/or chemically related to anabolic steroids. In the present study, we report the detection of a steroid in a product seized by the State Bureau of Criminal Investigation Schleswig-Holstein, Germany. The product "1-Androsterone" of the brand name "Advanced Muscle Science" was labeled to contain 100 mg of "1-Androstene-3b-ol,17-one" per capsule. The product was analyzed underivatized and as bis-TMS derivative by GC-MS. The steroid was identified by comparison with chemically synthesized 3β-hydroxy-5α-androst-1-en-17- one, prepared by reduction of 5α-androst-1-ene-3,17-dione with LS-Selectride (Lithium tris-isoamylborohydride), and by nuclear magnetic resonance. Semi-quantitation revealed an amount of 3β-hydroxy-5α- androst-1-en-17-one in the capsules as labeled. Following oral administration to a male volunteer, the main urinary metabolites were monitored. 1-Testosterone (17β-hydroxy-5α-androst-1-en-3-one), 1-androstenedione (5α-androst-1-ene-3,17-dione), 3α-hydroxy-5α-androst-1-en-17- one, 5α-androst-1-ene-3α,17β-diol, and 5α-androst-1-ene- 3β,17β-diol were detected besides the parent compound and two more metabolites (up to now not finally identified but most likely C-18 and C-19 hydroxylated 5α-androst-1-ene-3,17-diones). Additionally, common steroids of the urinary steroid profile were altered after the administration of "1-Androsterone". Especially the ratios of androsterone/ etiocholanolone and 5α-/5β-androstane-3α,17β-diol and the concentration of 5α-dihydrotestosterone were influenced. 3α-Hydroxy-5α-androst-1-en-17-one appears to be suitable for the long-term detection of the steroid (ab-)use, as this characteristic metabolite was detectable in screening up to nine days after a single administration of one capsule.