2365-26-6 Usage
Description
1-Formylisoquinoline thiosemicarbazone (IQ-1) is a small molecule compound that has been found to have significant effects on Wnt signaling, a critical pathway involved in various cellular processes and diseases. It is known to bind to the PR72/PR130 subunit of protein phosphatase PP2A, which in turn prevents β-catenin from switching co-activator usage from CBP to p300. This interaction leads to an increase in β-catenin/CBP-driven transcription at the expense of β-catenin/p300-driven transcription.
Uses
Used in Cell Proliferation and Stem Cell Maintenance:
1-Formylisoquinoline thiosemicarbazone is used as a regulator of Wnt signaling for maintaining murine embryonic stem cell proliferation in the absence of serum. IQ-1, in conjunction with Wnt3a, has been shown to be sufficient in sustaining stem cell proliferation, making it a valuable tool in stem cell research and potential therapeutic applications.
Used in Anticancer Applications:
1-Formylisoquinoline thiosemicarbazone is used as a potential anticancer agent, as it disrupts Wnt signaling, which is often dysregulated in various types of cancer. By targeting the PR72/PR130 subunit of protein phosphatase PP2A, IQ-1 can potentially inhibit the growth and progression of cancer cells that rely on aberrant Wnt signaling.
Used in Drug Development:
1-Formylisoquinoline thiosemicarbazone is used as a lead compound in the development of new drugs targeting Wnt signaling. Its ability to modulate the interaction between β-catenin and its co-activators makes it a promising starting point for designing novel therapeutics that can interfere with this critical pathway in disease contexts.
Check Digit Verification of cas no
The CAS Registry Mumber 2365-26-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,6 and 5 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2365-26:
(6*2)+(5*3)+(4*6)+(3*5)+(2*2)+(1*6)=76
76 % 10 = 6
So 2365-26-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N4S/c12-11(16)15-14-7-10-9-4-2-1-3-8(9)5-6-13-10/h1-7H,(H3,12,15,16)/b14-7-
