2365-80-2

Basic information

• Product Name: 2-Amino-5,5,5-trifluoropentanoic acid, 2-Amino-5,5,5-trifluorovaleric acid
• Synonyms: 2-Amino-5,5,5-trifluoropentanoic acid, 2-Amino-5,5,5-trifluorovaleric acid;5,5,5-Trifluoro-DL-norvaline 96%;Norvaline, 5,5,5-trifluoro-;5,5,5-Trifluoro-DL-norvaline96%
• CAS NO: 2365-80-2
• Molecular Formula: C₅H₈F₃NO₂
• Molecular Weight: 171.1177296
• Mol File: 2365-80-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 254-256 °C
• Boiling Point: 206.7°Cat760mmHg
• Flash Point: 78.8°C
• Appearance: /
• Density: 1.356g/cm³
• Storage Temp.: 2-8°C
• PKA: 2.17±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-5,5,5-trifluoropentanoic acid, 2-Amino-5,5,5-trifluorovaleric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5,5,5-trifluoropentanoic acid, 2-Amino-5,5,5-trifluorovaleric acid(2365-80-2)
• EPA Substance Registry System: 2-Amino-5,5,5-trifluoropentanoic acid, 2-Amino-5,5,5-trifluorovaleric acid(2365-80-2)

Safety Data

• Hazardous Substances Data: 2365-80-2(Hazardous Substances Data)

Usage

General Description

2-Amino-5,5,5-trifluoropentanoic acid and 2-Amino-5,5,5-trifluorovaleric acid are both chemical compounds containing an amino group and a trifluoromethyl group. These compounds are often used in pharmaceutical and chemical research as building blocks for more complex molecules. The trifluoromethyl group provides unique properties that can enhance the efficacy and stability of drugs and other compounds. These chemicals are also used in the synthesis of agrochemicals and specialty chemicals. Their unique structure and properties make them valuable in various industries for the development of new materials and compounds.

Upstream product

• 23809-63-4 5-(3,3,3-trifluoropropyl)imidazolidine-2,4-dione 
• 96563-56-3 N-acetyl-5,5,5-trifluoronorvaline 
• 118311-19-6 5,5,5-Trifluoro-2-[(Z)-hydroxyimino]-pentanoic acid 
• 120097-66-7 diethyl α-(N-acetylamino)-α-(3,3,3-trifluoropropyl)malonate 
• 406-87-1 4,4,4-trifluorobutanal 
• 143-33-9 sodium cyanide 
• 118311-18-5 5,5,5-trifluoro-2-oxopentanoic acid 
• 118325-20-5 5,5,5-Trifluoro-2-oxo-pentanoic acid tert-butylamide 
• 1859-47-8 2-(benzylamino)-5,5,5-trifluoropentanoic acid 

Downstream Products

• 1859-47-8 2-(benzylamino)-5,5,5-trifluoropentanoic acid 
• 122565-28-0 (S)-2-amino-5,5,5-trifluoropentanoic acid 
• 122565-29-1 (2R)-2-amino-5,5,5-trifluoropentanoic acid 

Relevant articles and documents

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MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

New and Effective Routes to Fluoro Analogues of Aliphatic and Aromatic Amino Acids

New and efficient syntheses of 4,4,4-trifluorovaline (1), 5,5,5-trifluoronorvaline (2), 5,5,5-trifluoroleucine (5), 6,6,6-trifluoronorleucine (6), 4,5,6,7-tetrafluorotryptophan (25), and α-(trifluoromethyl)-β-alanine are studied.Trifluorovaline (1) and trifluoronorvaline (2) are synthesized through amidocarbonylation of 2-(trifluoromethyl)propanal (2-TFMPA) and 3-(trifluoromethyl)propanal (3-TFMPA), respectively, followed by hydrolysis.Trifluoroleucine (5) and trifluoronorleucine (6) are synthesized by using modified Erlenmeyer's azlactone method from 2-TFMPA and 3-TFMPA, respectively. (S)- and (R)-trifluoronorvalines and trifluoronorleucines with high enantiomeric purities (95-100percent ee) are obtained through enzymatic optical resolution of N-acetyltrifluoronorvaline (4) and N-acetyltrifluoronorleucine (17) with the use of a porcine kidney acylase I.Optically active trifluoronorleucine is also obtained via the asymmetric hydrogenation of (Z)-N-benzoyldehydrotrifluoroleucine ethyl ester (10a-Z) with a chiral rhodium catalyst, ClO4, followed by hydrolysis.Unexpectedly high diastereoselectivities (80-87percent ee) are observed in the hydrogenation of (Z)-N-benzoyldehydrotrifluoroleucine ethyl ester (11b) and (Z)-N-benzoyl-4-(pentafluorophenyl)dehydronorvaline (14-Z) over palladium/carbon. 4,5,6,7-Tetrafluorotryptophan (25) and 4,5,6,7-tetrahydrotryptamine (30) are synthesized from 3-formyl-4,5,6,7-tetrafluoroindole (22a) in 51percent (four steps) and 83percent (two steps) overall yields, respectively. 4,5,6,7-Tetrafluoroindoleacetic acid (28) is obtained from 1-acetyl-3-(acetoxymethyl)-4,5,6,7-tetrafluoroindole (23a) in four steps in 65percent overall yield.The 3-formyl- and 1-acetyl-3-(acetoxymethyl)tetrafluoroindoles (22a, 23a) are prepared through selenium dioxide oxidation of 1-acyl-3-methyl-4,5,6,7-tetrafluoroindole (21), which is obtained via the cyclization of a Schiff base of 2-(pentafluorophenyl)propanal (2-PFPPA), in good yields.