23668-00-0Relevant articles and documents
Induced europium CPL for the selective signalling of phosphorylated amino-acids and: O -phosphorylated hexapeptides
Neil, Emily R.,Fox, Mark A.,Pal, Robert,Parker, David
supporting information, p. 8355 - 8366 (2016/06/01)
Two bright, europium(iii) complexes based on an achiral heptadentate triazacyclononane ligand bearing two strongly absorbing chromophores have been evaluated for the selective emission and CPL signalling of various chiral O-phosphono-anions. Binding of O-
Discovery of the first histone deacetylase 6/8 dual inhibitors
Olson, David E.,Wagner, Florence F.,Kaya, Taner,Gale, Jennifer P.,Aidoud, Nadia,Davoine, Emeline L.,Lazzaro, Fanny,We?wer, Michel,Zhang, Yan-Ling,Holson, Edward B.
, p. 4816 - 4820 (2013/07/19)
We disclose the first small molecule histone deacetylase (HDAC) inhibitor (3, BRD73954) capable of potently and selectively inhibiting both HDAC6 and HDAC8 despite the fact that these isoforms belong to distinct phylogenetic classes within the HDAC family of enzymes. Our data demonstrate that meta substituents of phenyl hydroxamic acids are readily accommodated upon binding to HDAC6 and, furthermore, are necessary for the potent inhibition of HDAC8.
Antithrombotic agents
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, (2008/06/13)
Compounds of formula (I) : are antithrombotic agents, having utility in a variety of therapeutic areas including the prevention and/or treatment of deep vein thrombosis (DVT) after surgery, major medical illness, paralysis, malignancy, prolonged immobilis
