2368-93-6 Usage
Description
Ethyl 3,3-difluorobutyrate is an organic compound that features a difluoromethyl group attached to a butyrate ester. It is a key intermediate in the synthesis of various fluorinated compounds and plays a significant role in the development of pharmaceuticals and agrochemicals due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
Ethyl 3,3-difluorobutyrate is used as a synthetic intermediate for the production of fluoroalkyl esters and carboxylic acids. Its application is crucial in the development of new drugs with improved pharmacological properties, such as enhanced bioavailability, metabolic stability, and selectivity.
Used in Agrochemical Industry:
In the agrochemical industry, Ethyl 3,3-difluorobutyrate is utilized as a building block for the synthesis of novel fluorinated pesticides and agrochemicals. The introduction of fluorine atoms into these compounds can lead to increased potency, selectivity, and reduced environmental impact.
Used in SF4-mediated Deoxofluorination Reactions:
Ethyl 3,3-difluorobutyrate is employed in the preparation of fluoroalkyl esters and carboxylic acids through SF4-mediated deoxofluorination reactions of β-ketoesters. This method allows for the efficient incorporation of fluorine atoms into organic molecules, which can significantly alter their reactivity and biological activity.
Used in Hazard Management:
The use of Ethyl 3,3-difluorobutyrate also involves the management and mitigation of the hazards associated with SF4 usage. SF4 is a highly toxic and reactive gas, and its safe handling and application in chemical reactions are essential for the development of new fluorinated compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 2368-93-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,6 and 8 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2368-93:
(6*2)+(5*3)+(4*6)+(3*8)+(2*9)+(1*3)=96
96 % 10 = 6
So 2368-93-6 is a valid CAS Registry Number.
2368-93-6Relevant articles and documents
Semi-Industrial Fluorination of β-Keto Esters with SF 4: Safety vs Efficacy
Bugera, Maksym Y.,Khairulin, Andrii R.,Kliukovskyi, Denys V.,Ryabukhin, Sergey V.,Semenov, Sergey V.,Shevchenko, Valerii O.,Tarasenko, Karen V.,Trofymchuk, Serhii A.,Volochnyuk, Dmitriy M.
, p. 565 - 574 (2020/03/27)
The possibility of deoxofluorination of β-keto esters using SF 4 was investigated. The scope and limitation of the reaction were determined. The efficient method for the synthesis of β,β-difluorocarboxylic acids was elaborated based on the reaction. The set of mentioned acids, being the perspective building blocks for medicinal chemistry, were synthesized on multigram scale. The safety of SF 4 use was discussed. The described method does not improve upon the safety of using SF 4, but practical recommendations for working with the reagent are proposed. Despite the hazards of using toxic SF 4, a significant increase of efficacy in the synthesis of medicinal-chemistry-relevant building blocks, based on the reaction, in comparison with earlier described approaches is shown.
