237081-53-7

Basic information

• Product Name: Pyridine, 2-(2S)-oxiranyl- (9CI)
• Synonyms: Pyridine, 2-(2S)-oxiranyl- (9CI)
• CAS NO: 237081-53-7
• Molecular Formula: C7H7NO
• Molecular Weight: 121.13658
• Product Categories: PYRIDINE
• Mol File: 237081-53-7.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 227.6±20.0 °C(Predicted)
• Appearance: /
• Density: 1.191±0.06 g/cm3(Predicted)
• PKA: 4.52±0.19(Predicted)
• CAS DataBase Reference: Pyridine, 2-(2S)-oxiranyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(2S)-oxiranyl- (9CI)(237081-53-7)
• EPA Substance Registry System: Pyridine, 2-(2S)-oxiranyl- (9CI)(237081-53-7)

Safety Data

• Hazardous Substances Data: 237081-53-7(Hazardous Substances Data)

Upstream product

• 100-69-6 2-vinylpyridine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 3086-29-1 trimethylsulfonium chloride 
• 70775-39-2 dimethylsulfoxonium methylide 
• 2181-44-4 trimethylsulfonium methylsulfate 
• 1774-47-6 trimethylsulfoxonium iodide 
• 55967-97-0 2-bromo-1-(pyridin-2-yl)ethan-1-ol 
• 593-71-5 Chloroiodomethane 
• 73951-61-8 (R)-2-bromo-1-(pyridin-2-yl)ethan-1-ol 
• 40086-66-6 2-Bromoacetylpyridine 
• 55967-94-7 2-oxiranylpyridine 
• 769140-90-1 (R)-2-(1-hydroxy-2-chloroethyl)-pyridine 
• 109-04-6 2-bromo-pyridine 
• 55484-10-1 2-chloro-1-(pyridin-2-yl)ethanone 

Downstream Products

• 115462-72-1 2-(Phenoxy)-1-(2-pyridyl)ethanol Hydrochloride 
• 3944-00-1 (2-pyridinyl)-1,2-ethanediol 
• 162238-27-9 (S)-2-(1,2-dihydroxyethyl)pyridine 
• 308366-26-9 (1R)-1-(pyridin-2-yl)ethane-1,2-diol 
• 73908-30-2 (-)-(R)-2-Pyridylethylene oxide 

Relevant articles and documents

Enzymatic hydration of (18O)epoxides. Role of nucleophilic mechanisms.

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Microbiological transformations. Part 48: Enantioselective biohydrolysis of 2-, 3- and 4-pyridyloxirane at high substrate concentration using the Agrobacterium radiobacter AD1 epoxide hydrolase and its Tyr215Phe mutant

The epoxide hydrolase (EH) from Agrobacterium radiobacter AD1 wild type (ArWT) and its Tyr215Phe mutant were compared for the biocatalyzed hydrolytic kinetic resolution (BHKR) of 2-, 3- and 4-pyridyloxirane. The regioselectivity of the oxirane ring opening as well as the substrate concentration limit and the inhibitory effect of the diol were determined. A gram scale preparation of enantiopure 2-pyridyloxirane (ee>98%) at a concentration as high as 127 mM (15.5 g/L) could be achieved with each of these two enzymes.

Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates

The generation of highly unstable chloromethylmagnesium chloride in a continuous flow reactor and its reaction with aldehydes and ketones is reported. With this strategy, chlorohydrins and epoxides were synthesized within a total residence time of only 2.6 s. The outcome of the reaction can be tuned by simply using either a basic or an acidic quench. Very good to excellent isolated yields, up to 97%, have been obtained for most cases (30 examples).

Manganese(II)/Picolinic Acid Catalyst System for Epoxidation of Olefins

An in situ generated catalyst system based on Mn(CF3SO3)2, picolinic acid, and peracetic acid converts an extensive scope of olefins to their epoxides at 0 °C in 5 min, with remarkable oxidant efficiency and no evidence of radical behavior. Competition experiments indicate an electrophilic active oxidant, proposed to be a high-valent Mn = O species. Ligand exploration suggests a general ligand sphere motif contributes to effective oxidation. The method is underscored by its simplicity and use of inexpensive reagents to quickly access high value-added products.