23720-80-1

Basic information

• Product Name: nardosinone
• Synonyms: nardosinone;(3aR)-1,3aβ,4,7,8,9,9a,9bβ-Octahydro-1,1,9β,9aβ-tetramethyl-5H-naphtho[2,1-c][1,2]dioxol-5-one;1,1,9β,9aβ-Tetramethyl-3aβ,7,8,9,9a,9bβ-hexahydro-1H-naphtho[2,1-c][1,2]dioxole-5(4H)-one;(3aR,9R,9aR,9bS)-1,3a,4,7,8,9,9a,9b-Octahydro-1,1,9,9a-tetramethyl-5H-naphtho[2,1-c][1,2]dioxol-5-one;5H-Naphtho[2,1-c][1,2]dioxol-5-one,1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)-;Nardosinone, 98%, from Nardostachys jatamansi DC.
• CAS NO: 23720-80-1
• Molecular Formula: C₁₅H₂₂O₃
• Molecular Weight: 250.33338
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 23720-80-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 108-110℃
• Boiling Point: 330.2°Cat760mmHg
• Flash Point: 142°C
• Appearance: /
• Density: 1.11
• Vapor Pressure: 0.000169mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: -20°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: nardosinone(CAS DataBase Reference)
• NIST Chemistry Reference: nardosinone(23720-80-1)
• EPA Substance Registry System: nardosinone(23720-80-1)

Safety Data

• Hazardous Substances Data: 23720-80-1(Hazardous Substances Data)

Usage

Description

Nardosinone is a bioactive compound with neuroprotective properties, known for its ability to reduce neuronal injury and protect H9c2 cardiac cells from angiotensin II-induced hypertrophy, which may lead to heart failure. It also acts as an enhancer of nerve growth factor (NGF).

Uses

Used in Pharmaceutical Applications:
Nardosinone is used as a neuroprotective agent for reducing neuronal injury and protecting H9c2 cardiac cells from angiotensin II-induced hypertrophy, which may contribute to the development of heart failure.
Used in Cardiovascular Applications:
Nardosinone is used as a cardioprotective agent for its potential to prevent heart failure by mitigating the effects of angiotensin II-induced hypertrophy on H9c2 cardiac cells.
Used in Neurological Applications:
Nardosinone is used as an enhancer of nerve growth factor (NGF) for promoting nerve growth and potentially improving neurological function in various conditions.

InChI:InChI=1/C15H22O3/c1-9-6-5-7-10-11(16)8-12-13(15(9,10)4)14(2,3)18-17-12/h7,9,12-13H,5-6,8H2,1-4H3/t9-,12-,13+,15+/m1/s1

Upstream product

• 114339-93-4 aristol-1⁽¹⁰⁾-en-9-one 

Downstream Products

• 20489-11-6 nardosinone diol 
• 73879-47-7 1-Hydroxy-4,5-dimethyl-5,6-dihydro-naphthalin 
• 73879-46-6 4a,5-Dimethyl-1,4,4a,5,6,7-hexahydro-naphthalin-1-on 
• 73879-49-9 2-Hydroxy-4a,5-dimethyl-4-isopropenyl-1,4,4a,5,6,7-hexahydro-naphthalin-1-on 
• 73879-50-2 8-Hydroxy-4a,5-dimethyl-4-isopropenyl-1,4,4a,5,6,7-hexahydro-naphthalin-1-on 
• 73879-45-5 (4aS,5R)-3-Chloro-4a,5-dimethyl-4a,5,6,7-tetrahydro-4H-naphthalen-1-one 
• 73879-44-4 (8R,8aS)-4-Chloro-8,8a-dimethyl-6,7,8,8a-tetrahydro-1H-naphthalen-2-one 
• 73879-43-3 3-Chlor-4a,5-dimethyl-4-isopropenyl-1,4,4a,5,6,7-hexahydro-naphthalin-1-on 
• 53859-06-6 Desoxo-narchinol 
• 115356-19-9 (4S,4aR,5R)-4-Isopropenyl-4a,5-dimethyl-1,4,4a,5,6,7-hexahydronaphthalen-1-one 
• 73925-07-2 1-Hydroxy-4,5-dimethyl-5,6,7,8-tetrahydro-naphthalin 
• 73879-52-4 2-Hydroxy-4a,5-dimethyl-4-isopropyl-decahydro-naphthalin-1-on 
• 73879-51-3 (4S,4aR,5R)-4-Isopropenyl-2-methoxy-4a,5-dimethyl-4a,5,6,7-tetrahydro-4H-naphthalen-1-one 

Relevant articles and documents

DARSTELLUNG VON NARDOSINON AUS 1(10)-ARISTOLENON-(9) (GANSONGON)

The title compound 1 is formed from 1(10)-aristolenon-(9) (gansongon) (2) by liquid-phase autoxidation in the presence of different phenols.