237429-77-5Relevant articles and documents
Topoisomerase I inhibition and cytotoxicity of 5-bromo- and 5-phenylterbenzimidazoles
Rangarajan, Meera,Kim, Jung Sun,Sim, Sai-Peng,Liu, Angela,Liu, Leroy F.,LaVoie, Edmond J.
, p. 2591 - 2600 (2007/10/03)
Topoisomerase I is an enzyme that is essential for maintaining the three-dimensional structure of DNA during the processes of transcription, translation and mitosis. With the introduction of new clinical agents that are effective in poisoning topoisomeras