2375-03-3

Basic information

• Product Name: 6alpha-Methylprednisolone sodium succinate
• Synonyms: (6alpha,11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione monosodium salt;6ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT;6ALPHA-METHYLPREDNISOLONE 21-HEMISUCCINATE SODIUM SALT;6-ALPHA-METHYLPREDNISOLONE SODIUM SUCCINATE;1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-SUCCINATE, SODIUM SALT;METHPREDNISOLONE SODIUM SUCCINATE;METHYLPREDNISOLONE SODIUM SUCCINATE;11-beta,17,21-trihydroxy-6-alpha-methyl-1,4-pregnadiene-3,20-dione21-(sodium
• CAS NO: 2375-03-3
• Molecular Formula: C26H33O8.Na
• Molecular Weight: 496.53
• EINECS: 219-156-8
• Mol File: 2375-03-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 689.6 °C at 760 mmHg
• Flash Point: 230.7 °C
• Appearance: /lyophilized powder
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 6alpha-Methylprednisolone sodium succinate(CAS DataBase Reference)
• NIST Chemistry Reference: 6alpha-Methylprednisolone sodium succinate(2375-03-3)
• EPA Substance Registry System: 6alpha-Methylprednisolone sodium succinate(2375-03-3)

Safety Data

• Hazard Codes: T
• Statements: 61-40
• Safety Statements: 53-22-36/37/39-45
• WGK Germany: 3
• RTECS: TU4154060
• Hazardous Substances Data: 2375-03-3(Hazardous Substances Data)

Usage

Description

6alpha-Methylprednisolone sodium succinate, also known as 6alpha-methylprednisolone 21-hemisuccinate sodium salt, is a synthetic glucocorticoid derived from the corticosteroid class of drugs. It exhibits potent anti-inflammatory and immunosuppressive properties, making it a valuable compound in the medical field for various therapeutic applications.

Uses

Used in Pharmaceutical Industry:
6alpha-Methylprednisolone sodium succinate is used as an anti-inflammatory medication for the treatment of spinal cord injuries. Its potent anti-inflammatory action helps in reducing inflammation and promoting healing in such cases.
Used in Research and Development:
6alpha-Methylprednisolone sodium succinate is utilized in the investigation of glucocorticoid-induced osteonecrosis under hypoxic conditions. It is employed in various experimental setups, such as cell cytotoxicity assays, flow cytometry, and western blotting, to study its effects on the MC3T3-E1 osteoblast cell line.
Brand Names:
Some of the brand names under which 6alpha-Methylprednisolone sodium succinate is marketed include A-Methapred (Abbott), A-Methapred (Hospira), and Solu-Medrol (Pharmacia & Upjohn). These formulations are widely used in clinical settings for the treatment of various inflammatory and immunological conditions.

Biochem/physiol Actions

Glucocorticoid with slightly longer half-life than that of prednisolone.

InChI:InChI=1/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16?,17?,19-,23?,24-,25-,26-;/m0./s1