23772-87-4

Basic information

• Product Name: dicyclopropylacetaldehyde
• Synonyms: dicyclopropylacetaldehyde;2,2-Dicyclopropylacetaldehyde;α-Cyclopropylcyclopropaneacetaldehyde;Einecs 245-873-0
• CAS NO: 23772-87-4
• Molecular Formula: C8H12O
• Molecular Weight: 124.18028
• EINECS: 245-873-0
• Mol File: 23772-87-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 186.1°Cat760mmHg
• Flash Point: 59.5°C
• Appearance: /
• Density: 1.109g/cm³
• Vapor Pressure: 0.675mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: dicyclopropylacetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: dicyclopropylacetaldehyde(23772-87-4)
• EPA Substance Registry System: dicyclopropylacetaldehyde(23772-87-4)

Safety Data

• Hazardous Substances Data: 23772-87-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H12O/c9-5-8(6-1-2-6)7-3-4-7/h5-8H,1-4H2

Upstream product

• 822-93-5 1,1-dicyclopropylethylene 
• 67-56-1 methanol 
• 1121-37-5 dicyclopropyl ketone 
• 20763-19-3 (methoxymethylene)triphenylphosphorane 
• 34189-07-6 (1-cyclopropyl-2-methoxy-vinyl)cyclopropane 
• 2181-42-2 trimethylsulphonium iodide 

Downstream Products

• 53969-23-6 4,4-Dicyclopropyl-1,1-dimethoxycyclohexan 

Relevant articles and documents

MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

AMINO-ACID ANILIDES AS SMALL MOLECULE MODULATORS OF IL-17

The present invention relates to a compound according to formula I (I) and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

New prolyl endopeptidase inhibitors: In vitro and in vivo activities of azabicyclo[2.2.2]octane, azabicyclo[2.2.1]heptane, and perhydroindole derivatives

A series of potent and selective prolylendopeptidase (PEP) inhibitors of the α-keto heterocyclic type has been obtained by replacing the classical central proline of 1-[1-(4-phenylbutanoyl)-L-prolyl]pyrrolidine (SUAM 1221, 3) by non-natural amino acids PHI, ABO, and ABH. These 4-phenylbutanoyl side- chain-containing inhibitors exhibited potent in vitro inhibitory potencies with IC50 around 30 nM (compounds 24 and 25). Modulation of the side chain by replacement of the terminal phenyl ring by the dicyclopropyl moiety afforded derivatives 30 and 32 with improved potencies (IC50 between 10 and 20 nM). Furthermore, replacing the linear 4-phenylbutanoyl side chain by the (2-phenylcyclopropyl)carbonyl entity provided potent inhibitors with IC50 culminating at 0.9 nM on a rat cortex enzymatic preparation (compound 70). The configuration of the cyclopropyl ring had to be R,R in order to obtain not only a strong PEP inhibition in vitro but also a good activity in vivo, exemplified by inhibitor 68, which gave ID50 ip and po of 0.3 and 1 mg/kg, respectively. Finally, demonstration of the cognition-enhancing properties of compound 54 was given in the passive avoidance test using scopolamine- induced amnesia in the rat, where it dose dependently inhibited the scopolamine-induced decrease in avoidance response.