23779-14-8Relevant articles and documents
Photoredox-Catalyst-Enabled para-Selective Trifluoromethylation of tert-Butyl Arylcarbamates
Chen, Yujie,Huang, Zhibin,Jiang, Yaqiqi,Li, Bao,Ma, Nana,Shi, Daqing,Shu, Sai,Yang, Shan,Zhao, Yingsheng
supporting information, p. 19030 - 19034 (2021/08/09)
The direct incorporation of a trifluoromethyl group on an aromatic ring using a radical pathway has been extensively investigated. However, the direct highly para-selective C?H trifluoromethylation of a class of arenes has not been achieved. In this study, we report a light-promoted 4,5-dichlorofluorescein (DCFS)-enabled para-selective C?H trifluoromethylation of arylcarbamates using Langlois reagent. The preliminary mechanistic study revealed that the activated organic photocatalyst coordinated with the arylcarbamate led to para-selective C?H trifluoromethylation. Ten-gram scale reaction performs well highlighting the synthetic importance of this new protocol.
Benzothiazole derivatives and their uses
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Paragraph 0163; 0165; 0166; 0179; 0180; 0198; 0199, (2022/01/05)
The present invention relates to benzothiazole derivatives and their uses, specifically to compounds shown in formula I or stereoisomers thereof and pharmaceutically acceptable salts, solvates or prodrugs thereof, methods of preparation thereof, and pharmaceutical compositions containing the compounds, wherein the substituentsR1,R2,R8 , X, Y, Z, Q have the meaning given in the instruction manual. The present invention further relates to the application of compounds of formula I in the preparation of drugs for the treatment and / or prevention of sEH-mediated diseases, in particular in the preparation of drugs for the treatment of inflammatory diseases, cardiovascular and cerebrovascular diseases, diabetes mellitus, diabetic complications, diabetes-related diseases, fibrotic diseases, neurological and psychiatric diseases, pain, ulcerative diseases and the like.
Synthesis and biological potentials of 5-aryl-n-[4-(Trifluoromethyl) phenyl]-1,3,4-oxadiazol-2-amines
Ahsan, Mohamed Jawed,Hassan, Mohd. Zaheen,Jadav, Surender Singh,Geesi, Mohammed H.,Bakht, Mohammed Afroz,Riadi, Yassine,Salahuddin,Akhtar, Md. Sayeed,Mallick, Mohammad Nasar,Akhter, Md. Habban
supporting information, p. 133 - 140 (2020/02/04)
Oxadiazoles are an important class of heterocyclic compounds, having broad-spectrum activity. They were also reported as anticancer, and antioxidant agents, hence it is of significant importance to explore new oxadiazoles. A series of eleven (5-aryl-N-[4-