2378-25-8

Basic information

• Product Name: 2-Propen-1-one, 1-(3-fluorophenyl)-3-phenyl-
• CAS NO: 2378-25-8
• Molecular Formula: C15H11FO
• Molecular Weight: 226.25
• Mol File: 2378-25-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(3-fluorophenyl)-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(3-fluorophenyl)-3-phenyl-(2378-25-8)
• EPA Substance Registry System: 2-Propen-1-one, 1-(3-fluorophenyl)-3-phenyl-(2378-25-8)

Safety Data

• Hazardous Substances Data: 2378-25-8(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 455-36-7 1-(3-fluorophenyl)ethanone 
• 898764-21-1 1-(3-fluorophenyl)-3-phenylpropan-1-one 
• 100-52-7 benzaldehyde 

Downstream Products

• 1355253-96-1 3-(4-chlorophenyl)-1-{5-phenyl-3-(3-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}isoquinoline 
• 1262129-83-8 (E)-1-(3-fluorophenyl)-3-phenylprop-2-en-1-ol 
• 1155309-29-7 3-(3-fluorophenyl)-1,5-diphenyl-4,5-dihydro-1H-pyrazole 
• 1155309-37-7 1,3-bis(3-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole 
• 1155309-38-8 1-(3,5-difluorophenyl )-3-(3-fluorophenyl )-5-phenyl-4,5-dihydro-1H-pyrazole 

Relevant articles and documents

Iridium and copper supported on silicon dioxide as chemoselective catalysts for dehydrogenation and borrowing hydrogen reactions

High active ligand usually plays an important role during catalysis and synthesis chemistry. A new and efficient benzotriazole-pyridinyl-silane ligand (BPS) was designed, and the corresponding iridium and copper catalysts were synthesized and thoroughly characterized by means of EDS, TEM, and XPS. The resulting iridium composite revealed excellent catalytic activity for the reaction of tert-butanesulfinamide with benzyl alcohols, while copper catalyst could realize the synthesis of unsaturated carbonyl compounds through the reaction of benzyl alcohols with ketones. This provided an efficient method for selective synthesis of unsaturated carbonyl compounds from benzyl alcohols and ketones in high yields with good recovery performance.

Regioselective α-Deuteration of Michael Acceptors Mediated by Isopropylamine in D2O/AcOD

Site-specific hydrogen/deuterium exchange is an important method to access deuterated compounds for chemical and biological studies. Herein is reported the first method for the regioselective α-deuteration of enals and enones. The transformation features D2O and AcOD as deuterium sources and amines as organocatalysts. The deuteration strategy is scalable and works on enals with a variety of substituted arene or heterocycle motifs as well as enones. The method has been applied to the synthesis of deuterated drug precursors.

Hydroxyl- and Halogen-containing Chalcones for the Inhibition of LPS-stimulated ROS Production in RAW 264.7 Macrophages: Design, Synthesis and Structure–Activity Relationship Study

Oxidative stress due to overproduction of reactive oxygen species (ROS) plays a major role in inflammation, cancer, and neurodegenerative disorders. In this study, 60 chalcone derivatives with fluorine (F), trifluoromethyl (CF3), trifluoromethoxy (OCF3), chlorine (Cl), and bromine (Br) in ring A and with or without hydroxy (OH) in ring B were designed, synthesized, and screened for inhibitory activity against lipopolysaccharide (LPS)-stimulated ROS production in RAW 264.7 macrophages. Structure–activity relationship study revealed the importance of a hydroxyl moiety in ring B for enhancing inhibitory activity of ROS production. Furthermore, a hydroxyl group at the ortho-position is more essential for inhibition of ROS production followed by meta- and para-positions. Among all, compound 27 that contains para-chlorine moiety in ring A and ortho-hydroxy in ring B displayed the strongest inhibitory activity (IC50 = 3.42 μM) against LPS-stimulated ROS production in RAW264.7 macrophages.