23783-23-5

Basic information

• Product Name: Heptanoyl glycine
• Synonyms: Heptanoyl glycine;N-Heptanoylglycine;(HeptanoylaMino)acetic Acid;2-(HeptanoylaMino)acetic Acid;N-(1-Oxoheptyl)glycine;N-(carboxyMethyl)heptanaMide;Glycine, N-(1-oxoheptyl)-
• CAS NO: 23783-23-5
• Molecular Formula: C₉H₁₇NO₃
• Molecular Weight: 187.12
• Product Categories: Amino Acids & Derivatives;Diagnostic;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 23783-23-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 98 °C
• Boiling Point: 394.848 °C at 760 mmHg
• Flash Point: 192.597 °C
• Appearance: /
• Density: 1.054 g/cm³
• Storage Temp.: Room Temperature
• Solubility: Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 3.62±0.10(Predicted)
• CAS DataBase Reference: Heptanoyl glycine(CAS DataBase Reference)
• NIST Chemistry Reference: Heptanoyl glycine(23783-23-5)
• EPA Substance Registry System: Heptanoyl glycine(23783-23-5)

Safety Data

• Hazardous Substances Data: 23783-23-5(Hazardous Substances Data)

Usage

Description

Heptanoyl glycine is an acylglycine derivative found in urinary excretion. It is a compound that has potential applications in the medical field, particularly as a diagnostic tool for metabolic disorders.

Uses

Used in Medical Diagnostics:
Heptanoyl glycine is used as a diagnostic tool for metabolic disorders, providing valuable information that complements the analysis of organic acids and acylcarnitine profiles. Its presence in urinary excretion allows for the detection and monitoring of various metabolic conditions, aiding in the diagnosis and treatment of these disorders.

Upstream product

• 2528-61-2 Heptanoic acid chloride 
• 56-40-6 glycine 
• 574010-47-2 C₁₁H₂₁NO₃ 
• 111-14-8 oenanthic acid 

Downstream Products

• 107332-47-8 [1S-[1α,2α(Z),3α,4α]]-7-[3-[[[[(1-oxoheptyl)amino]acetyl]amino]methyl]-7-oxabicyclo[2.2.1] hept-2-yl]-5-heptenoic acid 
• 1407998-10-0 methyl 2-hexyl-5-phenyloxazole-4-carboxylate 
• 1407998-03-1 (Z)-methyl 2-heptanamido-3-phenylacrylate 

Relevant articles and documents

Repurposing the 3-Isocyanobutanoic Acid Adenylation Enzyme SfaB for Versatile Amidation and Thioesterification

Genome mining of microbial natural products enables chemists not only to discover the bioactive molecules with novel skeletons, but also to identify the enzymes that catalyze diverse chemical reactions. Exploring the substrate promiscuity and catalytic mechanism of those biosynthetic enzymes facilitates the development of potential biocatalysts. SfaB is an acyl adenylate-forming enzyme that adenylates a unique building block, 3-isocyanobutanoic acid, in the biosynthetic pathway of the diisonitrile natural product SF2768 produced by Streptomyces thioluteus, and this AMP-ligase was demonstrated to accept a broad range of short-chain fatty acids (SCFAs). Herein, we repurpose SfaB to catalyze amidation or thioesterification between those SCFAs and various amine or thiol nucleophiles, thereby providing an alternative enzymatic approach to prepare the corresponding amides and thioesters in vitro.

Bisthioamide-7-oxabicycloheptane prostaglandin analogs

Bisthioamide-7-oxabicycloheptane prostaglandin analogs are provided having the structural formula STR1 wherein A is --CH=CH-- or --CH2 --CH2 --; n is 1 to 5; R is CO2 H, CO2 lower alkyl or STR2 q is 1 to 12; and R1 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, lower alkyl-S-aryl-S-, arylalkyl-S-, STR3 (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

Bicycloheptane substituted diamide and its congener prostaglandin analogs

Bicycloheptane substituted amide prostaglandin analogs are provided having the structural formula STR1 wherein m is 0 to 4; A is --CH=CH-- or --CH2 --CH2 --; n is 1 to 5; Q is --CH=CH--, --CH2 --, STR2 or a single bond; R is CO2 H, CO2 alkyl, CO2 alkali metal, CO2 polyhydroxyamine salt, --CH2 OH, STR3 wherein R4 and R5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R4 and R5 being other than hydroxy and lower alkoxy; p is 1 to 4; R1 is H or lower alkyl; q is 1 to 12; R2 is H or lower alkyl; and R3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, lower alkyl-S-, aryl-S-, arylalkyl-S-, STR4 (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.