23784-83-0

Basic information

• Product Name: 4-methoxy-cinnamic acid diethylamide
• Synonyms: 4-methoxy-cinnamic acid diethylamide
• CAS NO: 23784-83-0
• Molecular Weight: 233.31
• Mol File: 23784-83-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 4-methoxy-cinnamic acid diethylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-cinnamic acid diethylamide(23784-83-0)
• EPA Substance Registry System: 4-methoxy-cinnamic acid diethylamide(23784-83-0)

Safety Data

• Hazardous Substances Data: 23784-83-0(Hazardous Substances Data)

Upstream product

• 2430-01-5 2-bromo-N,N-diethylacetamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 109-89-7 diethylamine 
• 42996-84-9 p-methoxycinnamoyl chloride 
• 201230-82-2 carbon monoxide 
• 136618-41-2 E-2'-p-methoxystyryl iodide 
• 97-77-8 disulfiram 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 34446-64-5 (E)-3-(4-methoxyphenyl)propenoyl chloride 
• 2315-36-8 2-Chloro-N,N-diethylacetamide 
• 921-88-0 N,N-diethyldichloroacetamide 

Downstream Products

• 80120-53-2 N,N-diethyl-4-methoxy-α-oxo-benzeneacetamide 

Relevant articles and documents

Electron-Catalyzed Aminocarbonylation: Synthesis of α,β-Unsaturated Amides from Alkenyl Iodides, CO, and Amines

Aminocarbonylation of alkenyl iodides with CO and amines proceeded under heating to produce α,β-unsaturated amides in good yields (23 examples, 71% average yield). This catalyst-free method exhibited good functional-group tolerance, and open a straightforward access to functionalized acrylamides, as illustrated by the synthesis of Ilepcimide. A hybrid radical/ionic mechanism involving chain electron transfer is proposed for this transformation.

Synthesis of Cinnamides via Amidation Reaction of Cinnamic Acids with Tetraalkylthiuram Disulfides Under Simple Condition

A facile and efficient methodology for the synthesis of cinnamides has been achieved under metal- and additive-free conditions. This method allows the efficient C–N cross-coupling of diverse cinnamic acids with tetraalkylthiuram disulfides through a simply mixing operation in 1,2-dichloroethane at 100 °C. The protocol provides a direct approach to cinnamides and is featured with readily available starting materials and broad substrate scope, which shows its practical synthetic value in organic synthesis.

AMIDATION METHOD AND ESTERIFICATION METHOD USING SULFONIC ACID HALIDE

PROBLEM TO BE SOLVED: To provide a safe and economical method for rapidly synthesizing amides and esters in high yield. SOLUTION: There is provided a method for amidating an amine or a derivative thereof using a sulfonic acid halide, where a sulfonic acid halide is allowed to act as an activator on a carboxylic acid or a derivative thereof to synthesize an active ester, and the active ester is reacted with an amine or a derivative thereof as a nucleophile to amidate the amine or the derivative thereof to obtain a corresponding amide or a derivative thereof. In a similar manner, a sulfonic acid halide is allowed to act as an activator on a carboxylic acid or a derivative thereof to synthesize an active ester, and the active ester is reacted with an alcohol or a derivative thereof as a nucleophile to esterify the alcohol or the derivative thereof to obtain a corresponding ester or a derivative thereof. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPO&INPIT