23796-95-4

Basic information

• Product Name: 1-phenyl-1,10-dicarba-closo-decaborane⁽¹⁰⁾
• CAS NO: 23796-95-4
• Molecular Weight: 196.687
• Mol File: 23796-95-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-phenyl-1,10-dicarba-closo-decaborane⁽¹⁰⁾(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-1,10-dicarba-closo-decaborane⁽¹⁰⁾(23796-95-4)
• EPA Substance Registry System: 1-phenyl-1,10-dicarba-closo-decaborane⁽¹⁰⁾(23796-95-4)

Safety Data

• Hazardous Substances Data: 23796-95-4(Hazardous Substances Data)

Upstream product

• 37099-59-5 1,10-C₂B₈H₈-1-HgCH₃-10-C₆H₅ 
• 52700-91-1 1,10-C₂B₈H₈-1-CHO-10-C₆H₅ 
• 52700-87-5 1,10-C₂B₈H₈-1-COCH₃-10-C₆H₅ 
• 52700-85-3 1,10-C₂B₈H₈-1-COC₆H₅-10-C₆H₅ 
• 37099-60-8 1,10-C₂B₈H₈-1-Pb(CH₃)3-10-C₆H₅ 
• 591-50-4 iodobenzene 
• 23653-23-8 closo-1,10-dicarbadecaborane 
• 23653-29-4 1-C₆H₅-1,6-C₂B₈H₉ 

Relevant articles and documents

Development of androgen receptor ligands by application of ten-vertex para-carborane as a novel hydrophobic core structure

We report here the design, synthesis, androgenic activity and anti-androgenic activity of novel derivatives of hexadecahedral 1,10-dicarba-closo-decaborane, which is generally called ten-vertex para-carborane. The synthesized compounds exhibited very high binding affinity for the androgen receptor and showed anti-androgenic activity toward the androgen-dependent SC-3 cell line. Two compounds also exhibited partial agonistic activity in SC-3 assay. The docking studies of carborane derivatives to AR demonstrate that ten-vertex carborane is useful for development of novel bioactive compounds as well as twelve-vertex carboranes that are well known to be versatile pharmacophores. Ten-vertex carborane, which has not previously been applied in the field of medicinal chemistry, appears to have potential as a hydrophobic pharmacophore with characteristic properties.