238428-24-5

Basic information

• Product Name: C-BIPHENYL-4-YL-METHYLAMINE HYDROCHLORIDE
• Synonyms: C-BIPHENYL-4-YL-METHYLAMINE HYDROCHLORIDE;[1,1'-Biphenyl]-4-MethanaMine, hydrochloride
• CAS NO: 238428-24-5
• Molecular Formula: C13H14ClN
• Molecular Weight: 219.70996
• Mol File: 238428-24-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: C-BIPHENYL-4-YL-METHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: C-BIPHENYL-4-YL-METHYLAMINE HYDROCHLORIDE(238428-24-5)
• EPA Substance Registry System: C-BIPHENYL-4-YL-METHYLAMINE HYDROCHLORIDE(238428-24-5)

Safety Data

• Hazardous Substances Data: 238428-24-5(Hazardous Substances Data)

Usage

General Description

C-BIPHENYL-4-YL-METHYLAMINE HYDROCHLORIDE is a chemical compound composed of a biphenyl structure with a methylamine group attached to one of the phenyl rings. The hydrochloride salt form of this compound makes it more stable and suitable for use in various industrial and pharmaceutical applications. It is commonly used as an intermediate in the synthesis of various organic compounds, and it also has potential applications in the field of medicinal chemistry. This chemical is known for its ability to participate in organic reactions, making it valuable in the development of new chemical compounds and materials. It is important to handle and use C-BIPHENYL-4-YL-METHYLAMINE HYDROCHLORIDE with care, as it may pose health and safety hazards if not properly managed.

Upstream product

• 712-76-5 N-(4-phenyl)benzylamine 
• 2920-38-9 4-cyano-1,1'-biphenyl 
• 3815-20-1 biphenyl-4-carboxylic acid amide 

Downstream Products

• 262371-18-6 1-([1,1’-biphenyl]-4-yl)-N-benzyl-N-methylmethanamine 
• 861342-35-0 methyl-(4-methyl-benzyl)-(4-phenyl-benzyl)-amine 
• 861376-27-4 (4-ethyl-benzyl)-methyl-(4-phenyl-benzyl)-amine 

Relevant articles and documents

Bicyclic (alkyl)(amino)carbene (BICAAC) as a metal-free catalyst for reduction of nitriles to amines

Bicyclic (alkyl)(amino)carbene (BICAAC) is introduced as a metal-free catalyst for the reduction of various nitriles to the corresponding amine hydrochloride salts in the presence of pinacolborane. Mechanistic investigations combining experiments and DFT calculations suggest a B-H addition to the carbene center, which acts as a carrier of the hydride source. This journal is

Cyclic (Alkyl)(amino)carbene Ligand-Promoted Nitro Deoxygenative Hydroboration with Chromium Catalysis: Scope, Mechanism, and Applications

Transition metal catalysis that utilizes N-heterocyclic carbenes as noninnocent ligands in promoting transformations has not been well studied. We report here a cyclic (alkyl)(amino)carbene (CAAC) ligand-promoted nitro deoxygenative hydroboration with cost-effective chromium catalysis. Using 1 mol % of CAAC-Cr precatalyst, the addition of HBpin to nitro scaffolds leads to deoxygenation, allowing for the retention of various reducible functionalities and the compatibility of sensitive groups toward hydroboration, thereby providing a mild, chemoselective, and facile strategy to form anilines, as well as heteroaryl and aliphatic amine derivatives, with broad scope and particularly high turnover numbers (up to 1.8 × 106). Mechanistic studies, based on theoretical calculations, indicate that the CAAC ligand plays an important role in promoting polarity reversal of hydride of HBpin; it serves as an H-shuttle to facilitate deoxygenative hydroboration. The preparation of several commercially available pharmaceuticals by means of this strategy highlights its potential application in medicinal chemistry.

Synthesis of Molybdenum Pincer Complexes and Their Application in the Catalytic Hydrogenation of Nitriles

A series of molybdenum(0), (I) and (II) complexes ligated by different PNP and NNN pincer ligands were synthesized and structurally characterized. Along with previously described Mo?PNP complexes Mo-1 and Mo-2, all prepared compounds were tested in the catalytic hydrogenation of aromatic nitriles to primary amines. Among the applied catalysts, Mo-1 is particularly well suited for the hydrogenation of electron-rich benzonitriles. Additionally, two aliphatic nitriles were transformed into the desired products in 80 and 86 percent, respectively. Moreover, catalytic intermediate Mo-1a was isolated and its role in the catalytic cycle was subsequently demonstrated.