23850-78-4

Basic information

• Product Name: isobutyloxirane
• Synonyms: isobutyloxirane;(2-Methylpropyl)oxirane;1,2-Epoxy-4-methylpentane;Nsc92739;Oxirane, (2-methylpropyl)-;Pentane, 1,2-epoxy-4-methyl-;2-isobutyloxirane
• CAS NO: 23850-78-4
• Molecular Formula: C₆H₁₂O
• Molecular Weight: 100.15888
• EINECS: 245-911-6
• Mol File: 23850-78-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 103.9°Cat760mmHg
• Flash Point: 9.5°C
• Appearance: /
• Density: 0.869g/cm³
• Vapor Pressure: 36.6mmHg at 25°C
• Refractive Index: 1.423
• CAS DataBase Reference: isobutyloxirane(CAS DataBase Reference)
• NIST Chemistry Reference: isobutyloxirane(23850-78-4)
• EPA Substance Registry System: isobutyloxirane(23850-78-4)

Safety Data

• Hazardous Substances Data: 23850-78-4(Hazardous Substances Data)

Usage

General Description

Isobutyloxirane, also known as 2-methyl-2,3-epoxybutane, is a chemical compound with the formula C5H10O. It is a colorless liquid with a slightly fruity odor. Isobutyloxirane is used as a solvent and as a precursor to produce various other chemicals. It is also used in the production of pharmaceuticals, pesticides, and other organic compounds. Isobutyloxirane is considered to be a hazardous chemical and proper safety precautions should be taken when handling and using this substance.

InChI:InChI=1/C6H12O/c1-5(2)3-6-4-7-6/h5-6H,3-4H2,1-2H3

Upstream product

• 87760-51-8 4-methylpentane-1,2-diol 
• 691-37-2 4-Methyl-1-pentene 
• 84055-72-1 4-methyl-1-chloro-2-pentanol 

Downstream Products

• 14314-21-7 (+/-)-ipsenol 
• 144343-12-4 2-isobutylcyclopropyl phenyl sulfone 
• 83022-91-7 4-Methyl-1-(1-phenylsulfanyl-cyclopropyl)-pentan-2-ol 
• 108-11-2 Methyl isobutyl carbinol 
• 626-89-1 4-Methyl-1-pentanol 
• 111221-88-6 Toluene-4-sulfonic acid 1-hydroxymethyl-3-methyl-butyl ester 
• 111221-87-5 2-hydroxy-4-methylpentyl-p-toluenesulfonate 
• 135574-63-9 penaresidin B 

Relevant articles and documents

Primary Alcohols via Nickel Pentacarboxycyclopentadienyl Diamide Catalyzed Hydrosilylation of Terminal Epoxides

The efficient and regioselective hydrosilylation of epoxides co-catalyzed by a pentacarboxycyclopentadienyl (PCCP) diamide nickel complex and Lewis acid is reported. This method allows for the reductive opening of terminal, monosubstituted epoxides to form unbranched, primary alcohols. A range of substrates including both terminal and nonterminal epoxides are shown to work, and a mechanistic rationale is provided. This work represents the first use of a PCCP derivative as a ligand for transition-metal catalysis.

Vinylidene Homologation of Boronic Esters and its Application to the Synthesis of the Proposed Structure of Machillene

Alkenyl boronic esters are important reagents in organic synthesis. Herein, we report that these valuable products can be accessed by the homologation of boronic esters with lithiated epoxysilanes. Aliphatic and electron-rich aromatic boronic esters provided vinylidene boronic esters in moderate to high yields, while electron-deficient aromatic and vinyl boronic esters were found to give the corresponding vinyl silane products. Through DFT calculations, this divergence in mechanistic pathway has been rationalized by considering the stabilization of negative charge in the C?Si and C?B bond breaking transition states. This vinylidene homologation was used in a short six-step stereoselective synthesis of the proposed structure of machillene, however, synthetic and reported data were found to be inconsistent.

Regioselectivity and diasteroselectivity in Pt(II)-mediated "green" catalytic epoxidation of terminal alkenes with hydrogen peroxide: Mechanistic insight into a peculiar substrate selectivity

Recently developed electron-poor Pt(II) catalyst 1 with the "green" oxidant 35% hydrogen peroxide displays high activity and complete substrate selectivity in the epoxidation of terminal alkenes because of stringent steric and electronic requirements. In the presence of isolated dienes bearing terminal and internal double bonds, epoxidation is completely regioselective toward the production of terminal epoxides. Insight into the mechanism is gained by means of a reaction progress kinetic analysis approach that underlines the peculiar role of 1 in activating both the alkene and H 2O2 in the rate-determining step providing a rare example of nucleophilic oxidation of alkenes by H2O2.