239-44-1

Basic information

• Product Name: benzimidazo(2,1-a)isoquinoline
• Synonyms: benzimidazo(2,1-a)isoquinoline
• CAS NO: 239-44-1
• Molecular Formula: C₁₅H₁₀N₂
• Molecular Weight: 218.25
• Mol File: 239-44-1.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: benzimidazo(2,1-a)isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: benzimidazo(2,1-a)isoquinoline(239-44-1)
• EPA Substance Registry System: benzimidazo(2,1-a)isoquinoline(239-44-1)

Safety Data

• Hazardous Substances Data: 239-44-1(Hazardous Substances Data)

Upstream product

• 22244-48-0 1-(benzotriazol-1-yl)isoquinoline 
• 140381-66-4 1,2,3,4-tetrahydro-2-(2-nitrophenyl)isoquinoline 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 577-19-5 2-nitrophenyl bromide 
• 38846-64-9 2-ethynylbenzaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 13797-20-1 isoquinolin-1-yl-phenyl-amine 
• 588-73-8 (Z)-β-bromostyrene 
• 6286-30-2 2,3-dibromo-3-phenylpropanoic acid 
• 100-52-7 benzaldehyde 
• 621-82-9 Cinnamic acid 
• 51-17-2 benzoimidazole 
• 536-74-3 phenylacetylene 
• 1532-71-4 1-bromoisoquinoline 

Relevant articles and documents

Direct Access to Dihydrobenzoimidazo[2,1-a]isoquinolines through Ruthenium-catalyzed Formal [4+2] Annulation

A facile and straightforward synthesis of benzoimidazo[2,1-a]isoquinolines through Ru(II)-catalyzed [4+2] annulation reaction of 2-aryl benzimidazole and styrene has been explored. Tentative mechanistic studies imply the current reaction involves sequential C?C/C?N bond formation through the ortho C?H activation of 2-aryl benzimidazole followed by C?N reductive elimination. This newly developed strategy is widely applicable and tolerates various 2-arylbenzimidazole and vinyl derivatives, and allows the attractive vehicle for direct construction of diverse C6-substituated benzoimidazoisoquinoline scaffold in good yields. (Figure presented.).

Rhodium-Catalyzed Annulative Coupling Using Vinylene Carbonate as an Oxidizing Acetylene Surrogate

Transition-metal-catalyzed C-H activation and subsequent oxidative cyclization with alkynes has been a powerful tool for the synthesis of polycyclic aromatic compounds. Despite the substantial progress in this field, it is still a significant challenge to establish synthetic methodologies for the construction of nonsubstituted vinylene-fused aromatics. We herein report a Rh(III)-catalyzed C-H/N-H annulation with vinylene carbonate as an acetylene surrogate. Vinylene carbonate also acts as an internal oxidant to regenerate the Rh(III) species in situ; thus, no external oxidant is required to trigger the oxidative annulation. This protocol is applicable to the direct synthesis of various N-heteroaromatics.

One-Pot Synthesis of Imidazolyl Isoquinolines under a Palladium-Catalyzed C-H Activation/Annulation (CHAA) Reaction

A microwave-assisted Pd-catalyzed one-pot C-H activation/annulation (CHAA) protocol has been developed for the synthesis of imidazo[2,1-a]isoquinolines and benzo[4,5]imidazo[2,1-a]isoquinolines. Further N-alkylation for the preparation of a series of the