23924-78-9

Basic information

• Product Name: 1,7-BIS(HYDROXYMETHYL)-M-CARBORANE
• Synonyms: 1,7-bis(hydroxymethyl)carborane;1,7-dicarbadodecaborane(12)-1,7-dimethanol;bis(hydroxymethyl)-m-carborane;1,7-BIS(HYDROXYMETHYL)-M-CARBORANE
• CAS NO: 23924-78-9
• Molecular Formula: C4H16B10O2
• Molecular Weight: 204.28
• Mol File: 23924-78-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,7-BIS(HYDROXYMETHYL)-M-CARBORANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,7-BIS(HYDROXYMETHYL)-M-CARBORANE(23924-78-9)
• EPA Substance Registry System: 1,7-BIS(HYDROXYMETHYL)-M-CARBORANE(23924-78-9)

Safety Data

• Hazardous Substances Data: 23924-78-9(Hazardous Substances Data)

Usage

Hazard

Low toxicity by ingestion. A moderate eye irritant.

Upstream product

• 50-00-0 formaldehyd 
• 17217-89-9 dilithio-m-carborane 
• 7732-18-5 water 
• 16986-24-6 1,7-dicarba-closo-dodecaborane⁽¹²⁾ 
• 42568-26-3 1.7-(CH₂OCOCH₃)2-1.7-C₂B₁₀H₁₀ 

Relevant articles and documents

Improved synthesis of MC4-PPEA and the biological evaluation of its hydroxymethyl derivative

Nicotinamide phosphoribosyltransferase (Nampt) is an intriguing target for the treatment of many diseases, including cancer. Previously, our group demonstrated that carborane clusters may be used to increase the potency of small molecule inhibitors of Nam

Preparation method of 1,7-m-carborane dihydroxyl substituted derivative

The invention relates to a preparation method of a 1,7-m-carborane dihydroxyl substituted derivative, and belongs to the technical field of organic synthesis of carborane derivatives. The invention provides the preparation method of the 1,7-m-carborane dihydroxyl substituted derivative. The method comprises the following steps: (1) decaborane is reacted with a compound shown in a formula VI, and separation is performed to obtain a compound shown in a formula III; (2) in an inert environment, the compound shown in the formula III is subjected to a rearrangement reaction at 200 to 400 DEG C, and separation is performed to obtain a compound shown in a formula II; (3) the compound shown in the formula II is subjected to an ester hydrolysis reaction, and separation is performed to obtain the 1,7-m-carborane dihydroxyl substituted derivative shown in a formula I. The method utilizes cheap and easily-available raw materials to prepare the 1,7-m-carborane dihydroxyl substituted derivative; the production cost of the 1,7-m-carborane dihydroxyl substituted derivative can be significantly reduced; the reaction process is gentle and easy to control; the product yield is high; a relatively good industrial application value is realized.

Greatly enhanced thermo-oxidative stability of polybenzoxazine thermoset by incorporation of m-carborane

Novel polybenzoxazine precursor containing m-carborane unit in the main-chain has been firstly synthesized through click reaction of diazidomethyl m-carborane (DAMC) and diacetylene bisbenzoxazine (DABB). Meanwhlie, the traditional polybenzoxazine precursor was also prepared through click reaction of diazidomethyl p-benzene (DAPB) and DABB as a control. 1H NMR was used to confirm the structures of the monomers and the resulting polymers. FT-IR and differential scanning calorimetry (DSC) were used to study the curing behavior of carborane-containing benzoxazine polymer (CCBP). Dynamic mechanical analysis (DMA) study demonstrated that the cured CCBP had high storage moduli and high Tg. Thermogravimetric analysis (TGA) and ablation test showed that the cured CCBP had outstanding thermo-oxidative stability. During thermal ablation of cured CCBP, organic material was degraded, and a passivation layer with oxidized m-carboranes was formed, which prevented the underlying polymer from further degradation.