2393-58-0 Usage
Description
(3a,5b,6b,7a)-3,6,7-trihydroxy-Cholan-24-oic acid, also known as α-Muricholic Acid, is a murine-specific primary bile acid derived from the breakdown of cholesterol in the liver. It plays a crucial role in the digestion and absorption of dietary fats and fat-soluble vitamins. Studies have linked α-Muricholic Acid to the understanding of complex signaling pathways of hepatic lipid abnormalities associated with type 2 diabetes, making it a potential treatment target for this condition.
Uses
Used in Pharmaceutical Industry:
α-Muricholic Acid is used as a therapeutic agent for the treatment of type 2 diabetes. It is involved in the regulation of hepatic lipid metabolism and has been shown to improve insulin sensitivity and glucose tolerance in mice with high-fat diet-induced obesity. The modulation of α-Muricholic Acid levels may provide a novel approach to managing and treating type 2 diabetes.
Used in Research and Development:
α-Muricholic Acid is used as a research tool for studying the complex signaling pathways of hepatic lipid abnormalities and their association with type 2 diabetes. It helps researchers understand the role of bile acids in metabolic disorders and develop new therapeutic strategies for the treatment of these conditions.
Used in Nutritional Studies:
α-Muricholic Acid is used in nutritional studies to investigate the effects of dietary interventions on bile acid metabolism. For example, the decrease in fecal levels of α-Muricholic Acid in mice with high-fat diet-induced obesity following the administration of soybean protein has been linked to increases in fecal Clostridium cluster XIVa, a major producer of secondary bile acids. This finding highlights the potential role of dietary components in modulating bile acid metabolism and their impact on overall health.
Used in Metabolic Syndrome Research:
α-Muricholic Acid is used in research focused on metabolic syndrome, a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes. The study of α-Muricholic Acid in mice switched from a high-fat to low-fat diet, which results in increased plasma, liver, and muscle levels of the bile acid, provides insights into the mechanisms underlying the development of metabolic syndrome and the potential therapeutic interventions targeting bile acid metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 2393-58-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,9 and 3 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2393-58:
(6*2)+(5*3)+(4*9)+(3*3)+(2*5)+(1*8)=90
90 % 10 = 0
So 2393-58-0 is a valid CAS Registry Number.
InChI:InChI=1/C24H40O5/c1-13(4-7-19(26)27)15-5-6-16-20-17(9-11-23(15,16)2)24(3)10-8-14(25)12-18(24)21(28)22(20)29/h13-18,20-22,25,28-29H,4-12H2,1-3H3,(H,26,27)/t13?,14-,15?,16?,17?,18+,20?,21+,22+,23-,24-/m1/s1
