23937-97-5

Basic information

• Product Name: 4-Phenyl-2-[(3,4,5-trimethoxybenzylidene)amino]thiazole
• Synonyms: 4-Phenyl-2-[(3,4,5-trimethoxybenzylidene)amino]thiazole
• CAS NO: 23937-97-5
• Molecular Formula: C₁₉H₁₈N₂O₃S
• Molecular Weight: 354.4228
• Mol File: 23937-97-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 530.9°Cat760mmHg
• Flash Point: 274.9°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: 4-Phenyl-2-[(3,4,5-trimethoxybenzylidene)amino]thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenyl-2-[(3,4,5-trimethoxybenzylidene)amino]thiazole(23937-97-5)
• EPA Substance Registry System: 4-Phenyl-2-[(3,4,5-trimethoxybenzylidene)amino]thiazole(23937-97-5)

Safety Data

• Hazardous Substances Data: 23937-97-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H18N2O3S/c1-22-16-9-13(10-17(23-2)18(16)24-3)11-20-19-21-15(12-25-19)14-7-5-4-6-8-14/h4-12H,1-3H3/b20-11+

Upstream product

• 2010-06-2 2-Amino-4-phenylthiazole 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 98-86-2 acetophenone 

Downstream Products

• 24050-97-3 (4-phenyl-thiazol-2-yl)-(3,4,5-trimethoxy-benzyl)-amine 
• 1392193-09-7 C₂₉H₂₆N₂O₄S₂ 
• 1392193-10-0 C₂₉H₂₆N₂O₅S₂ 
• 1392193-11-1 C₂₈H₂₄N₂O₅S₂ 
• 1392193-13-3 C₃₁H₃₀N₂O₇S₂ 
• 1392193-04-2 C₂₈H₂₄N₂O₄S₂ 
• 1392193-05-3 C₂₈H₂₃ClN₂O₄S₂ 
• 1392193-06-4 C₂₈H₂₃N₃O₆S₂ 
• 1392193-07-5 C₂₈H₂₄N₂O₅S₂ 
• 1392193-08-6 C₂₈H₂₃ClN₂O₄S₂ 
• 1252788-78-5 2-(3,4,5-trimethoxyphenyl)-3-(4-phenylthiazol-2-yl)thiazolidin-4-one 

Relevant articles and documents

Synthesis of 5-arylidine-2-(3, 4, 5-trimethoxyphenyl)-3-(4-phenylthiazol-2- yl)thiazolidin-4-one derivatives as a novel class of antimicrobial agents

The present work describes the synthesis and in vitro antimicrobial evaluation of 5-arylidine derivatives of 2～(3, 4, 5～trimethoxyphenyl) ～3～(4～ phenylthiazol～2～yl) thiazolidin～4～one (4). The reaction of 2～amino～4～phenylthiazole, 3,4,5 trimethoxybenzaldehyde and mercaptoacetic acid in presence of DCC yielded 2～(3,4,5～trimethoxyphenyl)～3～(4～phenylthiazol～2～yl) thiazolidin～4-one (4) and further 5-arylidne derivatives (5a-5k) were synthesized by the subsequent reaction of 4 withdifferent aryl aldehydes. All the synthesized compounds were characterized by standard spectroscopic techniques, evaluated their antibacterial and antifungal activity by agar well diffusion method. The compounds showed some interesting antibacterial activity. The substitution of 5～arylidne groups on new thiazolidinone (4) have resulted enhanced antibacterial activity. The compounds showed moderate antifungal activity in a scattered manner.