23978-85-0 Usage
Description
II-NOR-9-TETRAHYDROCANNABINOL-9-CARBOXYLIC ACID (THC-COOH) (5 is a diterpenoid compound that serves as a biosynthetic precursor to Delta-9-tetrahydrocannabinol (THC), the primary psychoactive constituent found in the cannabis plant. It is characterized by its 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene structure, which is substituted at position 1 by a hydroxy group, positions 6, 6, and 9 by methyl groups, and at position 3 by a pentyl group.
Uses
Used in Pharmaceutical Industry:
THC-COOH (5 is used as a precursor compound for the synthesis of Delta-9-tetrahydrocannabinol (THC), which has various medical applications. THC is known for its analgesic, anti-inflammatory, and antiemetic properties, making it useful in the treatment of chronic pain, inflammation, and nausea associated with chemotherapy.
Used in Research and Development:
THC-COOH (5 is used as a research compound to study the effects of cannabinoids on the human body. This helps in understanding the potential therapeutic applications of cannabinoids and contributes to the development of new drugs and therapies based on the knowledge gained from these studies.
Used in Drug Metabolism Studies:
As a metabolite of THC, THC-COOH (5 is used in drug metabolism studies to understand how the body processes and eliminates cannabinoids. This information is crucial for determining the dosage, efficacy, and safety of cannabinoid-based medications.
Used in Forensic Toxicology:
THC-COOH (5 is utilized as a biomarker in forensic toxicology to detect the presence of cannabinoids in biological samples, such as blood or urine. This is particularly important in cases where individuals are suspected of driving under the influence of cannabis or in workplace drug testing.
Used in Quality Control and Standardization of Cannabinoid Products:
THC-COOH (5 is employed as a reference compound for the quality control and standardization of cannabinoid products, ensuring their purity, potency, and consistency. This is essential for maintaining the safety and efficacy of these products for medical and recreational use.
Check Digit Verification of cas no
The CAS Registry Mumber 23978-85-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,9,7 and 8 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 23978-85:
(7*2)+(6*3)+(5*9)+(4*7)+(3*8)+(2*8)+(1*5)=150
150 % 10 = 0
So 23978-85-0 is a valid CAS Registry Number.
InChI:InChI=1/C22H30O4/c1-5-6-7-8-14-12-17-19(20(23)18(14)21(24)25)15-11-13(2)9-10-16(15)22(3,4)26-17/h11-12,15-16,23H,5-10H2,1-4H3,(H,24,25)/t15-,16-/m1/s1
23978-85-0Relevant articles and documents
CANNABINOID DERIVATIVES
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Paragraph 0144, (2021/04/10)
This disclosure relates generally to cannabinoid derivatives having the formula (I), wherein R4 is hydrogen, -C(Q1)N(R4a)(R4b) or -C(R4J)(R4k)N(R4e)C(0)R4f, R6 is hydrogen, -C(Q2)N(R6a)(R6b) or -C(R6J)(R6k)N(R6e)C(0)R6f, provided that R6 is not hydrogen when R4 is hydrogen. Pharmaceutical compositions for the prevention or treatment of a disease associated with a cannabinoid receptor (such as CB1 or CB2) in a subject in need thereof, and methods of using the cannabinoid derivatives are also described.
PROCESS FOR PURIFICATION OF CANNABINOIC ACIDS FROM PLANT MATERIAL EXTRACT
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Paragraph 0037, (2020/02/14)
The present invention relates to a highly economic process for the purification of a cannabinoid acid, more specifically THCA or CBDA, from either a crude cannabis plant material or a cell culture of said cannabis plant, using ion exchange resins. The purified cannabinoid acid obtained may then be decarboxylated to yield the corresponding cannabinoid, i.e., THC or CBD, respectively.
SYNTHESIS OF PHYTOCANNABINOIDS INCLUDING A DEMETHYLATION STEP
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, (2019/03/05)
A method for demethylating a methylated phytocannabinoid compound of Formula I to form a phytocannabinoid compound of Formula II: Formula I Formula II wherein: R1 is selected from the group consisting of: substituted or unsubstituted C1-C5 alkyl; R2 is selected from the group consisting of: OH or O, and R3 is selected from the group consisting of: a substituted or unsubstituted cyclohexene, a substituted or unsubstituted C2-C8 alkene, or a substituted or unsubstituted C2-C8 dialkene; or R2 is O, and R2 and R3 together form a ring structure in which R2 is an internal ring atom; wherein the method includes: heating a reaction mixture comprising the methylated phytocannabinoid compounds and a polar aprotic solvent in the presence of a dissolved inorganic alkaline salt for a time sufficient to demethylate at least a portion of the methylated phytocannabinoid compounds and form the phytocannabinoid compound.