23981-25-1 Usage
Description
8-Chloro-2-hydroxyquinoline, also known as 8-chloroquinolin-2(1H)-one, is an organic compound with the molecular formula C9H6ClNO. It is a derivative of quinoline, featuring a chlorine atom at the 8th position and a hydroxyl group at the 2nd position. 8-CHLORO-2-HYDROXYQUINOLINE is known for its chemical properties and potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
8-Chloro-2-hydroxyquinoline is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
8-Chloro-2-hydroxyquinoline is used as a building block in the synthesis of complex organic molecules. It can be further modified and combined with other chemical groups to create a wide range of compounds with diverse properties and applications.
Used in Research and Development:
8-Chloro-2-hydroxyquinoline serves as a valuable research tool in the field of organic chemistry. It is used to study the properties and reactivity of quinoline derivatives, which can lead to the discovery of new compounds with potential applications in various industries.
Specific Applications:
8-Chloro-2-hydroxyquinoline is used to synthesize 8-chloro-2-(2-oxo-2-phenylethoxy)quinoline and 8-chloro-2-(2-oxopropoxy)quinolone. These synthesized compounds may have specific applications in various fields, such as pharmaceuticals, materials science, or chemical research.
Check Digit Verification of cas no
The CAS Registry Mumber 23981-25-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,9,8 and 1 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 23981-25:
(7*2)+(6*3)+(5*9)+(4*8)+(3*1)+(2*2)+(1*5)=121
121 % 10 = 1
So 23981-25-1 is a valid CAS Registry Number.
23981-25-1Relevant articles and documents
Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines
Angeli, Andrea,Trallori, Elena,Carta, Fabrizio,Di Cesare Mannelli, Lorenzo,Ghelardini, Carla,Supuran, Claudiu T.
supporting information, p. 947 - 951 (2018/09/12)
We have synthesized a new series of coumarin-based compounds demonstrating high selectivity and potent effects with low nanomolar affinity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA IX and XII. A number of these compounds were evaluated ex vivo against human prostate (PC3) and breast (MDA-MB-231) cancer cell lines. Compounds 4b and 15 revealed effective cytotoxic effects after 48 h of incubation in both normoxic and hypoxic conditions with PC3 cancer cell line. However, compound 3 showed selective cytotoxic effects against MDA-MB-231 in hypoxic condition. These results may be of particular importance for the choice of future drug candidates targeting hypoxic tumors and metastases, considering the fact that a selective carbonic anhydrase CA IX inhibitor (SLC-0111) is presently in phase II clinical trials.
NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS
-
Page/Page column 183, (2011/12/02)
Unsaturated nitrogen heterocyclic compounds of formula (I): (I), as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
Cardiotonic agents. 2. Synthesis and structure-activity relationships in a new class of 6-, 7-, and 8-pyridyl-2(1H)-quinolone derivatives
Leclerc,Marciniak,Decker,Schwartz
, p. 2433 - 2438 (2007/10/02)
-
