2401-25-4

Basic information

• Product Name: 4-CHLORO-3-IODOANISOLE
• Synonyms: 4-CHLORO-3-IODOANISOLE;1-chloro-2-iodo-4-methoxybenzene;1-Chloro-2-iodo-4-methoxybenzene, 4-Chloro-3-iodophenyl methyl ether
• CAS NO: 2401-25-4
• Molecular Formula: C₇H₆ClIO
• Molecular Weight: 268.48
• Product Categories: Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds;Iodine Compounds
• Mol File: 2401-25-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 284.8°C at 760 mmHg
• Flash Point: 126°C
• Appearance: /
• Density: 1.82g/cm³
• Vapor Pressure: 0.00501mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLORO-3-IODOANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-IODOANISOLE(2401-25-4)
• EPA Substance Registry System: 4-CHLORO-3-IODOANISOLE(2401-25-4)

Safety Data

• Hazardous Substances Data: 2401-25-4(Hazardous Substances Data)

Usage

Description

4-CHLORO-3-IODOANISOLE is an organic compound characterized by its chloro and iodo substituents on the anisole framework. It is known for its unique chemical properties and potential applications in various fields.

Uses

Used in Chemical Synthesis:
4-CHLORO-3-IODOANISOLE is used as a synthetic intermediate for the production of various organic compounds. Its unique structure allows it to be a versatile building block in the synthesis of complex molecules.
Used in Pharmaceutical Industry:
4-CHLORO-3-IODOANISOLE is used as a key component in the development of new drugs. Its specific functional groups can be exploited to create novel therapeutic agents with potential applications in treating various diseases.
Used in Enantioselective Synthesis:
4-CHLORO-3-IODOANISOLE is used as a chiral auxiliary in enantioselective carbocycle formation through intramolecular Pd-catalyzed allyl-aryl cross-coupling. This application is particularly relevant in the synthesis of enantiomerically pure compounds, which are essential in the pharmaceutical industry due to their potential for improved efficacy and reduced side effects.
Used in Material Science:
4-CHLORO-3-IODOANISOLE can be used as a component in the development of new materials with specific properties. Its unique structure may contribute to the creation of materials with tailored characteristics for various applications, such as in electronics, coatings, or adhesives.

InChI:InChI=1/C7H6ClIO/c1-10-5-2-3-6(8)7(9)4-5/h2-4H,1H3

Upstream product

• 2401-24-3 2-chloro-5-methoxyaniline 
• 10298-80-3 2-chloro-5-methoxynitrobenzene 
• 766-85-8 3-methoxy-1-iodobenzene 
• 89694-46-2 2-chloro-5-methoxyphenylboronic acid 

Downstream Products

• 199473-17-1 (E)-1-(2-Chloro-5-methoxyphenyl)-2-(2-naphthyl)ethene 
• 608131-00-6 1-chloro-2-hex-1-ynyl-4-methoxy-benzene 
• 608131-10-8 tert-butyl-[1-(2-chloro-5-methoxy-benzyl)-pentyl]-amine 
• 608131-09-5 [1-(2-chloro-5-methoxy-benzyl)-pentyl]-p-tolyl-amine 
• 202982-72-7 4-chloro-3-iodophenol 
• 1061316-80-0 2-(2-chloro-5-methoxyphenylthio)-1-(pent-4-ynyl)-1H-imidazo[4,5-c]pyridin-4-amine 
• 1095510-18-1 1-chloro-4-methoxy-2-phenylethynyl-benzene 
• 1168155-58-5 N-(2-chloro-5-methoxyphenyl)-2-nitro-3-(trifluoromethyl)aniline 
• 1400704-12-2 (S)-2-({2-[3-(2-chloro-5-methoxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester 
• 1400704-48-4 (S)-2-({2-[3-(2-chloro-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 

Relevant articles and documents

PYRIMIDINE AMIDE COMPOUNDS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.

Dehalogenation of o-dihalogen substituted arenes and α,α′-dihalogen substituted o-xylenes with lanthanum metal

It was found that lanthanum metal caused the dehalogenation of o-dihalogen substituted arenes and α,α′-dihalogen substituted o-xylenes to generate the corresponding benzynes and o-quinodimethanes. When o-dihalogen substituted arenes were allowed to react with lanthanum metal in the presence of dienes, the Diels-Alder products between benzyne and dienes were formed in moderate to good yields. Similarly, the Diels-Alder adducts of o-quinodimethane with dienophiles were obtained, in the reaction of α,α′-dibromo-o-xylenes with lanthanum metal in the presence of dienophiles.