24027-80-3 Usage
General Description
2',3'-Dideoxyadenosine triphosphoric acid (DDATP) is a modified form of the nucleotide adenosine that is used in research and diagnostic applications. It is similar to adenosine triphosphate (ATP), the main energy source for cellular processes, but with two oxygen atoms removed from the ribose sugar moiety at the 2' and 3' positions. This modification prevents the formation of a phosphodiester linkage, effectively terminating DNA synthesis when it is incorporated into a growing DNA strand by DNA polymerase. DDATP is often used in nucleic acid sequencing and other molecular biology techniques to study the structure and function of DNA and RNA. Additionally, it has potential applications in antiviral drug development due to its ability to inhibit viral DNA synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 24027-80-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,0,2 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 24027-80:
(7*2)+(6*4)+(5*0)+(4*2)+(3*7)+(2*8)+(1*0)=83
83 % 10 = 3
So 24027-80-3 is a valid CAS Registry Number.
24027-80-3Relevant articles and documents
Anti-retroviral agents and delivery systems for the same
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, (2008/06/13)
The present invention provides a method for preventing or treating disease caused by retroviruses, particularly human immunodeficiency virus. Liposomes are prepared containing phosphorylated derivatives of nucle-osides which act as chain-terminators of viral DNA. The phosphorylated nucleosides perse, without encapsulation in liposomes, do not readily enter cells. However, they are found to be effective if encapsulated in liposomes because they remain in liposomes longer, they do not escape easily from cells, and they constitute the active form for incorporation in viral DNA chains. When administered to a host, the liposomes are taken up by endocytic and phagocytic cells, which are important reservoirs of HIV infection. If coated with an appro-priate ligand, such as an immunoglobulin molecule, lipo-somes containing the phosphorylated nucleosides can be directed to phagocytic cells, CD4-positive cells, or infected host cells.
