24056-59-5

Basic information

• Product Name: 3,3-diphenylpiperidin-2-one
• CAS NO: 24056-59-5
• Molecular Formula: C₁₇H₁₇NO
• Molecular Weight: 251.323
• Mol File: 24056-59-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 449.7°C at 760 mmHg
• Flash Point: 272.2°C
• Density: 1.113g/cm³
• Vapor Pressure: 2.79E-08mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: 3,3-diphenylpiperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-diphenylpiperidin-2-one(24056-59-5)
• EPA Substance Registry System: 3,3-diphenylpiperidin-2-one(24056-59-5)

Safety Data

• Hazardous Substances Data: 24056-59-5(Hazardous Substances Data)

Upstream product

• 3469-00-9 methyl 2,2-diphenylacetate 
• 107-13-1 acrylonitrile 
• 2997-24-2 Ethyl 4-cyano-2,2-diphenylbutanoate 
• 3468-99-3 ethyl diphenylacetate 
• 2997-26-4 3,3-diphenyl-piperidine-2,6-dione 
• 117-34-0 2,2-diphenylacetic acid 

Downstream Products

• 391858-17-6 3,3-Diphenylpiperidine-2-thione 
• 1096168-47-6 7-chloro-4,4-diphenyl-1,2,3,4-tetrahydro-benzo[4,5]imidazo[1,2-a]pyridine 
• 1219624-63-1 ethyl 2-(2-oxo-3,3-diphenylpiperidin-1-yl)acetate 
• 4238-70-4 3,3-diphenyl-piperidine 
• 1219625-91-8 tert-butyl 4-(2-(2-oxo-3,3-diphenylpiperidin-1-yl)-N-(4-(trifluoromethyl)phenyl)acetamido)piperidine-1-carboxylate 
• 60011-04-3 (2-oxo-3,3-diphenyl-piperidin-1-yl)-acetic acid 
• 1334536-61-6 2-(2-oxo-3,3-diphenylpiperidin-1-yl)-N-piperidin-4-ylacetamide 
• 1334536-62-7 3,3-dimethyl-4-[(2-oxo-3,3-diphenylpiperidin-1-yl)acetyl]piperazin-2-one 
• 1334536-84-3 tert-butyl 4-(2-(2-oxo-3,3-diphenylpiperidin-1-yl)acetamido)piperidine-1-carboxylate 
• 1219624-62-0 A-1048400 
• 1219624-77-7 1-(2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-oxoethyl)-3,3-diphenylpiperidin-2-one 
• 1219624-76-6 1-{2-[4-(3-chlorobenzyl)piperazin-1-yl]-2-oxoethyl}-3,3-diphenylpiperidin-2-one 
• 1219625-94-1 1-{2-[4-(2,4-dichlorobenzyl)piperazin-1-yl]-2-oxoethyl}-3,3-diphenylpiperidin-2-one 
• 1219624-74-4 1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpiperidin-2-one 

Relevant articles and documents

Discovery of diphenyl lactam derivatives as N-type calcium channel blockers

A novel series of diphenyl lactam containing calcium channel blockers is described. Extensive SAR studies resulted in compounds with low molar activity and good plasma exposure after oral dosing. Compounds 2, 6 and 7 demonstrated significant efficacy in the capsaicin model of secondary hyperalgesia following oral administration.

NOVEL COMPOUNDS AS CALCIUM CHANNEL BLOCKERS

The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar1, Ar2, L1, L2, n, R1, R4, X and Y are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Intramolecular Schmidt reactions of alkyl azides with ketones: Scope and stereochemical studies

The intramolecular Schmidt reaction of alkyl azides and ketones has been demonstrated. The reaction is proposed to occur via initial attack of an azide on a ketone activated by a variety of protic or Lewis acids, including trifluoroacetic acid, titanium tetrachloride, and others. The resulting azidohydrin undergoes a direct rearrangement to afford the product amide and molecular nitrogen. When cyclic ketones are used, fused bicyclic lactams of types encountered in a wide variety of natural products are obtained. Although the distance allowed between the carbonyl group and the alkyl azide is quite restricted, the reaction is general with respect to the ketone component, including acyclic ketones and cyclic substrates ranging from standard to large ring sizes. The reaction also succeeds with aldehydes, although elimination or hydride migration products compete. In several cases examined the reaction was found to proceed with retention of configuration at the migrating carbon. Competing reactions with β-diketones and α,β-unsaturated ketones were found to predominate over ring expansion.