240820-24-0Relevant articles and documents
Coumarin-based prodrugs 2. Synthesis and bioreversibility studies of an esterase-sensitive cyclic prodrug of DADLE, an opioid peptide
Wang, Binghe,Wang, Wei,Zhang, Huijuan,Shan, Daxian,Smith, Terrill D.
, p. 2823 - 2826 (1996)
A coumarin-based esterase-sensitive cyclic prodrug of an opioid peptide, DADLE, was prepared. The cyclic prodrug quickly released (t( 1/4 ) = 761 min) its original peptide, DADLE, upon esterase catalyzed hydrolysis. Such a system can be used for the preparation of cyclic prodrugs of other biologically active peptides aimed at improving their bioavailability.