24083-16-7Relevant articles and documents
New double-chain and aromatic (α-hydroxyalkyl)phosphorus amphiphiles
Brun, Alice,Etemad-Moghadam, Guita
, p. 1385 - 1390 (2002)
New double-chain bis-(α-hydroxyalkyl)phosphinic acids 1 are synthesized from NaH2PO2·H2O and aliphatic aldehydes. Direct and quantitative one-pot synthesis of new 4-alkoxybenzaldehydes 2 is realized from 1-bromoalkanes and
A pH-responsive superamphiphile based on dynamic covalent bonds
Wang, Chao,Wang, Guangtong,Wang, Zhiqiang,Zhang, Xi
, p. 3322 - 3325 (2011)
Under pH control: A successful example of a toothbrush-type superamphiphile based on dynamic covalent bonds is demonstrated. The superamphiphile can self-assemble in water to form spherical aggregates, which disassemble reversibly under mildly acidic cond
Highly packed and stretched polyterpyridinyl Ru2+ complexes and their photophysical and stability properties
Liu, Die,Jiang, Zhilong,Wang, Meng,Yang, Xiaoyu,Liu, Haisheng,Wu, Tun,Wang, Pingshan
, p. 293 - 298 (2016)
Two unique trinuclear terpyridine-ruthenium complexes having similar components placed at different angels were successfully synthesized and fully characterized for the purpose of determining the photophysical and electronic properties. The corresponding
Lipophilic tail modifications of 2-(hydroxymethyl)pyrrolidine scaffold reveal dual sphingosine kinase 1 and 2 inhibitors
Li, Hao,Sibley, Christopher D.,Kharel, Yugesh,Huang, Tao,Brown, Anne M.,Wonilowicz, Laura G.,Bevan, David R.,Lynch, Kevin R.,Santos, Webster L.
, (2021/01/07)
The sphingosine 1-phosphate (S1P) signaling pathway is an attractive target for pharmacological manipulation due to its involvement in cancer progression and immune cell chemotaxis. The synthesis of S1P is catalyzed by the action of sphingosine kinase 1 or 2 (SphK1 or SphK2) on sphingosine and ATP. While potent and selective inhibitors of SphK1 or SphK2 have been reported, development of potent dual SphK1/SphK2 inhibitors are still needed. Towards this end, we report the structure–activity relationship profiling of 2-(hydroxymethyl)pyrrolidine-based inhibitors with 22d being the most potent dual SphK1/SphK2 inhibitor (SphK1 Ki = 0.679 μM, SphK2 Ki = 0.951 μM) reported in this series. 22d inhibited the growth of engineered Saccharomyces cerevisiae and decreased S1P levels in histiocytic lymphoma myeloid cell line (U937 cells), demonstrating inhibition of SphK1 and 2 in vitro. Molecular modeling studies of 22d docked inside the Sph binding pocket of both SphK1 and SphK2 indicate essential hydrogen bond between the 2-(hydroxymethyl)pyrrolidine head to interact with aspartic acid and serine residues near the ATP binding pocket, which provide the basis for dual inhibition. In addition, the dodecyl tail adopts a “J-shape” conformation found in crystal structure of sphingosine bound to SphK1. Collectively, these studies provide insight into the intermolecular interactions in the SphK1 and 2 active sites to achieve maximal dual inhibitory activity.
Aggregation-induced emissions in the mesogenic BF2complexes of aroylhydrazines
Cai, Yi-Hong,Chih, Hsin-Yun,Lai, Chung K.,Lee, Gene-Hsiang
, p. 12557 - 12568 (2021/07/25)
Herein, we report the synthesis of two new families of borondifluoride complexes derived from aroylhydrazines and the investigation of their mesomorphic and AIE properties. The crystallographic structure of the mesogenic complex1a-BF2(n= 8) was
