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24138-83-8

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24138-83-8 Usage

Description

5-[(4-chlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione, also known as pioglitazone, is a chemical compound that belongs to the class of thiazolidinediones. It is commonly used as a medication for treating type 2 diabetes due to its anti-hyperglycemic and anti-inflammatory properties. Pioglitazone works by increasing the body's sensitivity to insulin, which helps in better control of blood sugar levels.

Uses

Used in Pharmaceutical Industry:
5-[(4-chlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione is used as an anti-hyperglycemic and anti-inflammatory medication for the treatment of type 2 diabetes. It enhances insulin sensitivity, leading to improved blood sugar control.
Used in Comprehensive Treatment Plans:
5-[(4-chlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione is often prescribed in combination with other diabetes medications as part of a comprehensive treatment plan to manage type 2 diabetes effectively.

Check Digit Verification of cas no

The CAS Registry Mumber 24138-83-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,1,3 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 24138-83:
(7*2)+(6*4)+(5*1)+(4*3)+(3*8)+(2*8)+(1*3)=98
98 % 10 = 8
So 24138-83-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H6ClNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)

24138-83-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-[(4-chlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione

1.2 Other means of identification

Product number -
Other names (2E,4Z)-2,4-heptadienal

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:24138-83-8 SDS

24138-83-8Relevant articles and documents

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Lo et al.

, p. 4845 (1953)

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Permuted 2,4-thiazolidinedione (TZD) analogs as GLUT inhibitors and their in-vitro evaluation in leukemic cells

Aguilera, Renato J.,Choe, Jun-yong,Hess, Jessica D.,Iancu, Cristina V.,Macias, Lucasantiago Henze,Meyer-Almes, Franz-Josef,Mrowka, Piotr,Ramaa, C. S.,Schweipert, Markus,Tilekar, Kalpana,Upadhyay, Neha

, (2020/08/21)

Cancer is a heterogeneous disease, and its treatment requires the identification of new ways to thwart tumor cells. Amongst such emerging targets are glucose transporters (GLUTs, SLC2 family), which are overexpressed by almost all types of cancer cells; t

A class of carbonic anhydrase IX/XII–selective carboxylate inhibitors

Alhameed, Rakia Abd,Almarhoon, Zainab,Berrino, Emanuela,El-Faham, Ayman,Supuran, Claudiu T.

, p. 549 - 554 (2020/02/13)

A small series of 2,4-dioxothiazolidinyl acetic acids was prepared from thiourea, chloroacetic acid, aromatic aldehydes, and ethyl-2-bromoacetate. They were assayed for the inhibition of four physiologically relevant carbonic anhydrase (CA, EC 4.2.1.1) isoforms of human (h) origin, the cytosolic hCA I and II, and the transmembrane hCA IX and XII, involved among others in tumorigenesis (hCA IX and XII) and glaucoma (hCA II and XII). The two cytosolic isoforms were not inhibited by these carboxylates, which were also rather ineffective as hCA IX inhibitors. On the other hand, they showed submicromolar hCA XII inhibition, with KIs in the range of 0.30–0.93 μM, making them highly CA XII-selective inhibitors.

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