24152-41-8

Basic information

• Product Name: 4-PHENETHYL-PIPERIDINE
• Synonyms: CHEMBRDG-BB 4012233;ASINEX-REAG BAS 12229133;4-PHENETHYL-PIPERIDINE;4-(2-PHENYLETHYL)PIPERIDINE;AKOS BBS-00006839;TIMTEC-BB SBB010816;4-(2-phenylethyl)piperidine(SALTDATA: HCl);Piperidine, 4-(2-phenylethyl)-
• CAS NO: 24152-41-8
• Molecular Formula: C₁₃H₁₉N
• Molecular Weight: 189.3
• Mol File: 24152-41-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 289.6 °C at 760 mmHg
• Flash Point: 130.5 °C
• Appearance: /
• Density: 0.942 g/cm³
• Vapor Pressure: 0.00218mmHg at 25°C
• Refractive Index: 1.511
• PKA: 10.69±0.10(Predicted)
• CAS DataBase Reference: 4-PHENETHYL-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENETHYL-PIPERIDINE(24152-41-8)
• EPA Substance Registry System: 4-PHENETHYL-PIPERIDINE(24152-41-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 24152-41-8(Hazardous Substances Data)

Usage

General Description

4-Phenethyl-piperidine is a chemical compound with the molecular formula C13H19N. It is a piperidine derivative that contains a phenethyl group, which is a common structure found in many psychoactive and pharmaceutical compounds. 4-Phenethyl-piperidine has been studied as a potential antidepressant and antipsychotic agent, as well as a potential treatment for addictive disorders. It has also been investigated for its potential to act as a dopamine receptor agonist. Additionally, 4-phenethyl-piperidine has shown to have analgesic properties, making it a potential candidate for pain management. Overall, 4-phenethyl-piperidine is a versatile compound that has drawn interest for its potential therapeutic benefits in various medical applications.

InChI:InChI=1/C13H19N/c1-2-4-12(5-3-1)6-7-13-8-10-14-11-9-13/h1-5,13-14H,6-11H2

Upstream product

• 5097-93-8 trans-4-styrylpyride 
• 108-89-4 picoline 
• 100-52-7 benzaldehyde 

Downstream Products

• 102886-39-5 3-[2-(4-phenethyl-piperidin-1-yl)-ethyl]-indole 
• 857940-40-0 4-Phenethyl-1-((E)-3-phenyl-allyl)-piperidine 
• 1227862-64-7 6-(4-phenethylpiperidin-1-yl)pyridin-3-amine 

Relevant articles and documents

Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2

A small library of fluoroethoxy-1,4-diphenethyl piperidine and fluoroethoxy-1,4-diphenethyl piperazine derivatives were designed, synthesized and evaluated for their ability to inhibit [3H]dopamine (DA) uptake at the vesicular monoamine transporter-2 (VMAT2) and dopamine transporter (DAT), [3H]serotonin (5-HT) uptake at the serotonin transporter (SERT), and [3H]dofetilide binding at the human-ether-a-go-go-related gene (hERG) channel. The majority of the compounds exhibited potent inhibition of [3H]DA uptake at VMAT2, Ki changes in the nanomolar range (Ki = 0.014–0.073 μM). Compound 15d exhibited the highest affinity (Ki = 0.014 μM) at VMAT2, and had 160-, 5-, and 60-fold greater selectivity for VMAT2 vs. DAT, SERT and hERG, respectively. Compound 15b exhibited the greatest selectivity (>60-fold) for VMAT2 relative to all the other targets evaluated, and 15b had high affinity for VMAT2 (Ki = 0.073 μM). Compound 15b was considered the lead compound from this analog series due to its high affinity and selectivity for VMAT2.

1,4-DISUBSTITUTED PIPERIDINES, 1,4-DISUBSTITUTED PIPERAZINES, 1,4-DISUBSTITUTED DIAZEPANES, AND 1,3-DISUBSTITUTED PYRROLIDINE COMPOUNDS

The present invention is directed to 1,4-disubstituted piperidines, 1,4-disubstituted piperazines, 1,4-disubstituted diazepanes, and 1,3-disubstituted pyrrolidine compounds and their use.

Lobelane analogues as novel ligands for the vesicular monoamine transporter-2

A series of lobelane analogues has been synthesized and their structure-activity relationships at the vesicular monoamine transporter-2 (VMAT2) have been evaluated. The most potent analogues in this series were the cis-2,6-piperidino analogues, 25b, 27b, 28b, and 30b, with Ki values ranging from 430 to 580 nM.