24202-71-9

Basic information

• Product Name: 2,5-Pyridinedicarboxylic acid, 5-(phenylmethyl) ester
• CAS NO: 24202-71-9
• Molecular Formula: C14H11NO4
• Molecular Weight: 257.246
• Mol File: 24202-71-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2,5-Pyridinedicarboxylic acid, 5-(phenylmethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Pyridinedicarboxylic acid, 5-(phenylmethyl) ester(24202-71-9)
• EPA Substance Registry System: 2,5-Pyridinedicarboxylic acid, 5-(phenylmethyl) ester(24202-71-9)

Safety Data

• Hazardous Substances Data: 24202-71-9(Hazardous Substances Data)

Upstream product

• 24202-70-8 pyridine-2,5-dicarboxylic acid dibenzyl ester 
• 100-26-5 Pyridine-2,5-dicarboxylic acid 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Discovery of novel Syk/PDGFR-α/c-Kit inhibitors as multi-targeting drugs to treat rheumatoid arthritis

Due to the complex biological pathways involved in rheumatoid arthritis, discovery of multi-targeting small molecules provides an effective strategy to achieve better efficacy and lower toxicity. Herein the first Syk/PDGFR-α/c-Kit inhibitors were designed and evaluated. Dihydrofuropyrimidine derivative 13 showed potent inhibitory activity against the three targets. Importantly, compound 13 exhibited good cellular efficacy against fibroblast-like synoviocytes (IC50 = 3.21 μM) and mouse bone marrow-derived mast cells (IC50 = 2.03 μM) and significantly decreased the secretion of inflammatory cytokines. Thus, Syk/PDGFR-α/c-Kit triple inhibitor 13 represented a promising lead compound for the treatment of RA.

FIVE-MEMBERED HETEROCYCLIC DERIVATIVE

The present invention relates to a compound represented by formula (I): a salt of the compound, or a solvate of the compound or the salt; a drug containing any of the compounds, the salts, and the solvates; a preventive and/or therapeutic agent for an ischemic disease containing any of the compounds, the salts, and the solvates; and a platelet coagulation inhibitor containing any of the compounds, the salts, and the solvates. The compound of the present invention is useful as a strong platelet coagulation inhibitor without inhibiting COX-1 or COX-2.

Preparation of monoesters of pyridine-dicarboxylic acids

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