24220-92-6

Basic information

• Product Name: 4(1H)-Quinolinone, 1-(phenylmethyl)-
• CAS NO: 24220-92-6
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Mol File: 24220-92-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 4(1H)-Quinolinone, 1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinolinone, 1-(phenylmethyl)-(24220-92-6)
• EPA Substance Registry System: 4(1H)-Quinolinone, 1-(phenylmethyl)-(24220-92-6)

Safety Data

• Hazardous Substances Data: 24220-92-6(Hazardous Substances Data)

Upstream product

• 15619-48-4 1-benzylquinolin-1-ium chloride 
• 611-36-9 quinolin-4-ol 
• 100-51-6 benzyl alcohol 
• 62-53-3 aniline 
• 529-37-3 4(1H)-quinolinone 
• 100-39-0 benzyl bromide 
• 551-93-9 2-aminoacetophenone 
• 154010-87-4 1-[2-(benzylamino)phenyl]propan-1-one 
• 758640-21-0 N-Benzylaniline 
• 110-91-8 morpholine 

Downstream Products

• 1358531-76-6 1-benzyl-3-(perfluorophenyl)quinolin-4(1H)-one 
• 1358531-78-8 1-benzyl-3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)quinolin-4(1H)-one 
• 1619229-42-3 (E)-1-benzyl-5-(1,2-diphenylvinyl)quinolin-4(1H)-one 
• 1617537-45-7 3-(benzo[d]thiazol-2-yl)-1-benzylquinolin-4(1H)-one 
• 1617537-55-9 1-benzyl-3-(6-chlorobenzo[d]oxazol-2-yl)quinolin-4(1H)-one 
• 1617537-56-0 1-benzyl-3-(5-phenyloxazol-2-yl)quinolin-4(1H)-one 
• 1617537-57-1 1-benzyl-3-(5-phenyl-1,3,4-oxadiazol-2-yl)quinolin-4(1H)-one 
• 1617537-58-2 1-benzyl-3-(1-benzyl-1H-benzo[d]imidazol-2-yl)quinolin-4(1H)-one 
• 1309362-39-7 1-benzyl-3-iodoquinolin-4(1H)-one 

Relevant articles and documents

Cu(I)-Catalyzed Alkynylation of Quinolones

Herein we report the first alkynylation of quinolones with terminal alkynes under mild reaction conditions. The reaction is catalyzed by Cu(I) salts in the presence of a Lewis acid, which is essential for the reactivity of the system. The enantioselective version of this transformation has also been explored, and the methodology has been applied in the synthesis of the enantioenriched tetrahydroquinoline alkaloid cuspareine.

Highly Enantioselective Catalytic Addition of Grignard Reagents to N-Heterocyclic Acceptors

General methods to prepare chiral N-heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2- and 4-substituted tetrahydro-quinolones, dihydro-4-pyridones, and piperidones with excellent yields and enantioselectivities, utilizing a single catalyst system.

Selectivity of N-versus O-alkylation in Mitsunobu reactions with various quinolinols and isoquinolinols

Reacting quinolinols and isoquinolinols under Mitsunobu conditions can give rise to N-alkylated products in addition to the normally desired O-alkylated structures. An in-depth study of how the solvent, reagent equivalents, position of the quinoline/isoqu