2430-93-5Relevant articles and documents
Stereoselective Ring-Opening of gem-Difluorocyclopropanes: An Entry to Stereo-defined (E,E)- and (E,Z)-Conjugated Fluorodienes
Specklin, Simon,Fenneteau, Johan,Subramanian, Parthasarathi,Cossy, Janine
supporting information, p. 332 - 336 (2018/01/17)
The ring-opening of gem-difluorocyclopropyl acetaldehydes producing selectively (E,E)- and (E,Z)-conjugated fluorodienals is described. Two stereo-divergent methods are presented to access both stereoisomers from a common precursor, in high yield and selectivity. The mechanistic aspect of these transformations is discussed.
Taming the carboxyl group for directed carbometalation: Observations on the use of anions, dianions and ester enolates
Desrat, Sandy,Gray, Philip J.,Penny, Matthew R.,Motherwell, William B.
supporting information, p. 8918 - 8922 (2014/07/22)
Carboxylate anions, dianions and ester enolates provide simultaneous protection and activation for directed carbometalation reactions. Advantage can be taken of the bis-carbanionic character of the intermediate for further controlled C-C bond forming reac
Method for regio- and stereoselective synthesis of (E)-Β,γ- unsaturated acids from aldehydes under solvent-free conditions
Zhang, Shi-Jie,Hu, Wei-Xiao
experimental part, p. 3093 - 3100 (2010/12/19)
Synthesis of (E)-β,-γunsaturated acids from aldehydes with malonic acid has been explored under solvent-free conditions. The modified Knoevenagel condensation reaction with N-methyl morpholine (NMM) as catalyst exhibits highly β,-γ regioselectivity and exclusively E-stereoselectivity. A mechanism accounting for both regio- and stereoselectivity has been proposed and preliminarily studied. Copyright Taylor & Francis Group, LLC.
