24301-86-8

Basic information

• Product Name: 1-phenyl-1-propanamine hydrochloride
• Synonyms: 1-phenyl-1-propanamine hydrochloride
• CAS NO: 24301-86-8
• Molecular Formula: C₉H₁₃N*ClH
• Molecular Weight: 171.66716
• Mol File: 24301-86-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 203.9°C at 760 mmHg
• Flash Point: 85.1°C
• Appearance: /
• Vapor Pressure: 0.272mmHg at 25°C
• CAS DataBase Reference: 1-phenyl-1-propanamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-1-propanamine hydrochloride(24301-86-8)
• EPA Substance Registry System: 1-phenyl-1-propanamine hydrochloride(24301-86-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 24301-86-8(Hazardous Substances Data)

Usage

Safety Profile

Poison by subcutaneous and intravenous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx.

InChI:InChI=1/C9H13N.ClH/c1-2-9(10)8-6-4-3-5-7-8;/h3-7,9H,2,10H2,1H3;1H

Upstream product

• 189387-89-1 diethyl N-(1-phenylpropyl)phosphoramidate 
• 180399-94-4 N-(Diethoxyphosphoryl)benzylideneimine 
• 79893-76-8 N-benzyl-benzolcarboximidsauremethylester 
• 83834-93-9 N-(1-phenylpropyl)formamide 
• 2157-50-8 propiophenone oxime 
• 93-54-9 1-Phenyl-1-propanol 
• 103-65-1 phenylpropane 
• 61357-38-8 propiophenone-imine; hydrochloride 

Downstream Products

• 769-60-8 2-methyl-1-phenylprop-2-en-1-one 
• 1019554-60-9 (1-phenyl-propylamino)-acetic acid methyl ester 
• 92255-96-4 DL-2-Mercapto-1-<1-phenyl-propyl>imidazol-5-carbonsaeure-methylester 
• 847448-01-5 [formyl-(1-phenyl-propyl)-amino]-acetic acid methyl ester 
• 141178-39-4 (S)-N-benzoyl-1-phenylpropylamine 
• 1349891-71-9 N⁶-[(+/-)-1-(phenyl)propyl]adenosine 

Relevant articles and documents

Chiral Bronsted Acids Catalyze Asymmetric Additions to Substrates that Are Already Protonated: Highly Enantioselective Disulfonimide-Catalyzed Hantzsch Ester Reductions of NH-Imine Hydrochloride Salts

While imines are frequently used substrates in asymmetric Bronsted acid catalysis, their corresponding salts are generally considered unsuitable reaction partners. Such processes are challenging because they require the successful competition of a catalytic amount of a chiral anion with a stoichiometric amount of an achiral one. We now show that enantiopure disulfonimides enable the asymmetric reduction of N-H imine hydrochloride salts using Hantzsch esters as hydrogen source. Our scalable reaction delivers crystalline primary amine salts in great efficiency and enantioselectivity and the discovery suggests potential of this approach in other Bronsted acid catalyzed transformations of achiral iminium salts. Kinetic studies and acidity data suggest a bifunctional catalytic activation mode.

Sustainable organophosphorus-catalysed Staudinger reduction

A highly efficient and sustainable catalytic Staudinger reduction for the conversion of organic azides to amines in excellent yields has been developed. The reaction displays excellent functional group tolerance to functionalities that are otherwise prone to reduction, such as sulfones, esters, amides, ketones, nitriles, alkenes, and benzyl ethers. The green nature of the reaction is exemplified by the use of PMHS, CPME, and a lack of column chromatography.

N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF

The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.