24303-04-6Relevant articles and documents
Aminocarbonylation of N -Containing Heterocycles with Aromatic Amines Using Mo(CO) 6
Mamone, Marius,Aziz, Jessy,Le Bescont, Julie,Piguel, Sandrine
, p. 1521 - 1526 (2018/01/27)
We describe herein the palladium-catalyzed aminocarbonylation of nitrogen-containing heterocycles with aniline derivatives using molybdenum hexacarbonyl as a CO solid source, expanding the scope of the limited examples. This method is compatible with a variety of substitutions on the aniline moiety. The simple reaction conditions include easily available Pd(dppf)Cl 2 catalyst, DBU as base in DMF at 120 °C for 3 hours in sealed tube thereby leading to the isolation of 21 compounds with yields ranging from 18 to 82%. We also show that double aminocarbonylation reactions are possible in satisfactory yields regarding both coupling partners.
A new application of parallel synthesis strategy for discovery of amide-linked small molecules as potent chondroprotective agents in TNF-α-stimulated chondrocytes
Lee, Chia-Chung,Lo, Yang,Ho, Ling-Jun,Lai, Jenn-Haung,Lien, Shiu-Bii,Lin, Leou-Chyr,Chen, Chun-Liang,Chen, Tsung-Chih,Liu, Feng-Cheng,Huang, Hsu-Shan
, (2016/03/30)
As part of an effort to profile potential therapeutics for the treatment of inflammation-related diseases, a diversity of amide-linked small molecules was synthesized by using parallel synthesis strategy. Moreover, these new compounds were also evaluated
