24310-24-5

Basic information

• Product Name: 1,2,3,4-Tetrahydro-1-(p-tolylsulfonyl)quinoline
• Synonyms: 1,2,3,4-Tetrahydro-1-(p-tolylsulfonyl)quinoline;1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroquinoline
• CAS NO: 24310-24-5
• Molecular Formula: C₁₆H₁₇NO₂S
• Molecular Weight: 287.38
• Mol File: 24310-24-5.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2,3,4-Tetrahydro-1-(p-tolylsulfonyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydro-1-(p-tolylsulfonyl)quinoline(24310-24-5)
• EPA Substance Registry System: 1,2,3,4-Tetrahydro-1-(p-tolylsulfonyl)quinoline(24310-24-5)

Safety Data

• Hazardous Substances Data: 24310-24-5(Hazardous Substances Data)

Upstream product

• 543745-59-1 N-[(4-methylphenyl)sulfonyl]-3-(2-bromophenyl)propylamine 
• 5435-02-9 4-methyl-N-(3-phenylpropyl)benzenesulfonamide 
• 953395-28-3 3-(2-(4-methylphenylsulfonamido)phenyl)propyl 4-pentynoate 
• 953395-31-8 3-(2-(4-methylphenylsulfonamido)phenyl)propyl 2-ethynylbenzoate 
• 953395-32-9 N-(2-(3-hydroxypropyl)phenyl)-4-methylbenzenesulfonamide 
• 57591-47-6 3-(2-aminophenyl)-1-propanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 583-55-1 1-Bromo-2-iodobenzene 
• 178809-30-8 3-(2-bromo-phenyl)-acrylonitrile 
• 65185-60-6 3-(2-bromophenyl)propan-1-amine 
• 61698-07-5 3-(2-bromo-phenyl)-propionitrile 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 1378521-80-2 C₁₆H₁₇BrINO₂S 
• 61613-20-5 N-tosyl-2-iodoaniline 

Downstream Products

• 14278-37-6 1-tosyl-2,3-dihydroquinolin-4(1H)-one 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Bismuth(iii)-catalyzed regioselective alkylation of tetrahydroquinolines and indolines towards the synthesis of bioactive core-biaryl oxindoles and CYP19 inhibitors

Bismuth(iii)-catalyzed regioselective functionalization at the C-6 position of tetrahydroquinolines and the C-5 position of indolines has been demonstrated. For the first time, one pot symmetrical and unsymmetrical arylation of isatins with tetrahydroquinolines was accomplished giving a completely new product skeleton in good to excellent yields. Most importantly, this protocol leads to the formation of a highly strained quaternary carbon stereogenic center, which is a challenging task. Benzhydryl and 1-phenylethyl trichloroacetimidates have been used as the alkylating partners to functionalize the C-6 and C-5 positions of tetrahydroquinolines and indolines, respectively. The scope of the developed methodology has been extended for the synthesis of the bioactive CYP19-inhibitor and its analogue.

Seven-membered rings through metal-free rearrangement mediated by hypervalent iodine

A versatile and metal-free approach for the synthesis of carbocycles and of heterocycles bearing seven- and eight-membered rings is described. The strategy is based on ring expansion of 1-vinylcycloalkanols (or the corresponding silyl or methyl ether) med

Nickel-mediated inter- and intramolecular reductive cross-coupling of unactivated alkyl bromides and aryl iodides at room temperature

A nickel-mediated intermolecular reductive cross-coupling reaction of unactivated alkyl bromides and aryl iodides at room temperature has been developed and successfully extended to less explored intramolecular versions and tandem cyclization-intermolecular cross-coupling. Highly stereoselective (or stereospecific) synthesis of linear-fused perhydrofuro[2,3-b]furan (pyran) and spiroketal skeletons allows rapid access to these useful building blocks, which would be potentially valuable in the synthesis of relevant natural products. A rational explanation for the formation of contiguous stereogenic centers is given. Copyright