24327-72-8Relevant articles and documents
Application of new isonicotinamides as a corrosion inhibitor on mild steel in acidic medium: Electrochemical, SEM, EDX, AFM and DFT investigations
Yadav,Sinha,Sarkar,Bahadur,Ebenso
, p. 686 - 698 (2015)
Corrosion inhibition effect of 2-(2-(2-phenyl)-3-(isonicotinamido)-4-oxothiazolidin-5-yl) acetic acid (PITA) and N-(2-phenyl-4-oxothiazolidin-3-yl)-isonicotinamide (POTI) on mild steel corrosion in 15% HCl solution was studied by using weight loss, electrochemical polarization and electrochemical impedance spectroscopy (EIS) techniques. It was found that the inhibition efficiency of both inhibitors increases with increase in concentration. The effect of temperature on the corrosion rate was investigated and some thermodynamic parameters were calculated. Polarization studies show that both studied inhibitors are of mixed type in nature. The results show that both POTI and PITA are good inhibitors, and the adsorption of each inhibitor on mild steel surface obeys Langmuir adsorption isotherm. Scanning electron microscopic (SEM), energy dispersive X-ray spectroscopic (EDX) and atomic force microscopy (AFM) studies were used to characterize the surface morphology of uninhibited and inhibited mild steel specimens. The morphological study indicated adsorption of inhibitor molecules on the surface of the mild steel. The density functional theory (DFT) was employed for theoretical calculations. The results obtained from experimental measurements and those from theoretical calculations are in good agreement.
Synthesis and antimicrobial activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide
Thomas, Asha B.,Nanda, Rabindra K.,Kothapalli, Lata P.,Deshpande, Avinash D.
scheme or table, p. 960 - 968 (2012/03/08)
A series of isonicotinyl hydrazones and their 4-thiazolidinones have been synthesized by condensation of isonicotinic acid hydrazide with various aromatic aldehydes to yield Schiff's bases, followed by the cyclocondensation of Schiff's bases with 2-mercaptoacetic acid to yield their 4-thiazolidinones. The synthesized compounds have been characterized by their elemental, analytical and spectral studies. All these compounds were evaluated for their invitro antimicrobial activity against a spectrum of non-resistant and resistant microbial organisms. These studies proved that compounds 5e,i against B. subtilis; 5e,f,h against B. anthracis; 5g,i against S. aureus showed good activity at lower concentrations. Compounds 5d-5i displayed significant activity against resistant strain of K. pneumonia with minimum inhibitory potency in the concentration range of 2-16 ug/ml.
Synthesis and antimycobacterial activity of a novel series of isonicotinylhydrazide derivatives
Jaju, Sandip,Palkar, Mahesh,Maddi, Veeresh S.,Ronad, Pradeepkumar,Mamledesai, Shivalingarao,Satyanarayana, Darbhamulla,Ghatole, Mangala
experimental part, p. 723 - 731 (2010/05/02)
A novel series of 14 new isonicotinyl hydrazide derivatives 2a-g, 3a-g containing a 4-thiazolidinone / 2-azetidinone nucleus were synthesized by reacting N9-substituted arylidene / heteroarylidene isonicotinyl hydrazide 1a-g with thioglycollic acid in the presence of dry benzene and with chloroacetyl chloride in the presence of triethylamine, respectively. Structures of all newly synthesized compounds were characterized on the basis of elemental analyses and spectral data (IR and 1H-NMR). All the title compounds were tested for their in-vitro antimycobacterial activity against Mycobacterium tuberculosis H 37Rv using Alamar-Blue susceptibility test, and the activity is expressed as the minimum inhibitory concentration (MIC) in μg/mL. Among the series, compounds 2b, 2g, 3b, and 3g displayed an encouraging antimycobacterial activity profile as compared to that of the reference drugs isoniazid / rifampicin.
